Small molecule inhibitors in acute myeloid leukemia: From the bench to the clinic

Muneera Al-Hussaini, John F. Dipersio

Research output: Contribution to journalReview articlepeer-review

19 Scopus citations

Abstract

Many patients with acute myeloid leukemia will eventually develop refractory or relapsed disease. In the absence of standard therapy for this population, there is currently an urgent unmet need for novel therapeutic agents. Targeted therapy with small molecule inhibitors represents a new therapeutic intervention that has been successful for the treatment of multiple tumors (e.g., gastrointestinal stromal tumors, chronic myelogenous leukemia). Hence, there has been great interest in generating selective small molecule inhibitors targeting critical pathways of proliferation and survival in acute myeloid leukemia. This review highlights a selective group of intriguing therapeutic agents and their presumed targets in both preclinical models and in early human clinical trials.

Original languageEnglish
Pages (from-to)439-464
Number of pages26
JournalExpert Review of Hematology
Volume7
Issue number4
DOIs
StatePublished - Aug 2014

Keywords

  • acute myeloid leukemia
  • small molecule inhibitor
  • therapeutic agent

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