TY - JOUR
T1 - Small molecule biaryl FSH receptor agonists. Part 1
T2 - Lead discovery via encoded combinatorial synthesis
AU - Guo, Tao
AU - Adang, Anton E.P.
AU - Dolle, Roland E.
AU - Dong, Guizhen
AU - Fitzpatrick, Dan
AU - Geng, Peng
AU - Ho, Koc Kan
AU - Kultgen, Steven G.
AU - Liu, Ruiyan
AU - McDonald, Edward
AU - McGuinness, Brian F.
AU - Saionz, Kurt W.
AU - Valenzano, Kenneth J.
AU - Van Straten, Nicole C.R.
AU - Xie, Dan
AU - Webb, Maria L.
PY - 2004/4/1
Y1 - 2004/4/1
N2 - High-throughput screening of two million compounds in 37 distinct encoded combinatorial libraries using FSH receptor transfected cells provided small molecule agonists such as 1 (EC50=3 μM) and 2 (EC50=3. 9 μM), based on which a focused combinatorial library with a total of 31,372 compounds was designed, synthesized, and screened to reveal 72 novel biaryl FSH receptor agonists such as 8a-c as well as a unique combinatorial SAR.
AB - High-throughput screening of two million compounds in 37 distinct encoded combinatorial libraries using FSH receptor transfected cells provided small molecule agonists such as 1 (EC50=3 μM) and 2 (EC50=3. 9 μM), based on which a focused combinatorial library with a total of 31,372 compounds was designed, synthesized, and screened to reveal 72 novel biaryl FSH receptor agonists such as 8a-c as well as a unique combinatorial SAR.
KW - Combinatorial synthesis
KW - Small molecule biaryl FSH agonists
UR - http://www.scopus.com/inward/record.url?scp=12144286406&partnerID=8YFLogxK
U2 - 10.1016/j.bmcl.2004.01.042
DO - 10.1016/j.bmcl.2004.01.042
M3 - Article
C2 - 15026056
AN - SCOPUS:12144286406
VL - 14
SP - 1713
EP - 1716
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
SN - 0960-894X
IS - 7
ER -