Small CD4+8+TCRlow thymocytes contain precursors of mature T cells

Wojciech Swat, Harald Von Boehmer, Pawel Kisielow

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

To evaluate directly the developmental potential of cortical CD4+8+ thymocytes, highly purified populations of small, nondividing CD4+8+TCRlow and large, dividing CD4+8+TCRhigh thymocytes from H‐2d mice expressing a transgenic T cell receptor restricted by H‐2Db (major histocompatibility complex class I) molecules were transferred into the thymus of normal, nonirradiated H‐2b recipient mice. The results show that both populations generate CD48+ thymocytes under these conditions, thus providing conclusive evidence that small cortical thymocytes do not represent a “dead end” but an important intermediate stage in T cell development.

Original languageEnglish
Pages (from-to)1010-1012
Number of pages3
JournalEuropean Journal of Immunology
Volume24
Issue number4
DOIs
StatePublished - Apr 1994
Externally publishedYes

Keywords

  • Cortical thymocytes
  • Positive selection
  • T cell precursors

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