@inproceedings{4c25cec03e2c44808a30caea32b72c2d,
title = "Small animal imaging using a curved array photoacoustic tomography system",
abstract = "We report experimental imaging results with mice using an array-based photoacoustic tomography system designed for small animal imaging. The system features a 128-element curved transducer array with stage rotation to enable complete two-dimensional tomographic imaging in less than 15 seconds. High fidelity imaging of ex vivo mouse brain vasculature was achieved with resolution of vessels less than 200 microns in diameter in the cortex as well as the cerebellum. Images obtained using varying measurement surface angular spans clearly illustrate the impact on feature definition with orientation. The high sensitivity of the system was demonstrated by images of the brain vasculature with an overlying turbid medium (μa=0.03 cm-1 and μs′∼7 cm-1 at 780 nm) of over 2 cm depth. In phantom experiments, high-quality images of blood tubing in a turbid medium were achieved at depths greater than 3 cm for incident fluences of less than 15 mJ/cm2. These results illustrate the suitability for near real-time small animal imaging of deep tissue with high definition.",
keywords = "Optical tomography, Phased array ultrasound, Photoacoustic tomography, Small animal imaging",
author = "John Gamelin and Andres Aguirre and Anastasios Maurudis and Fei Huang and Diego Castillo and Wang, \{Lihong V.\} and Quing Zhu",
year = "2008",
month = feb,
day = "29",
doi = "10.1117/12.769238",
language = "English",
isbn = "9780819470317",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
publisher = "SPIE",
booktitle = "Photons Plus Ultrasound",
note = "9th Conference on Photons Plus Ultrasound: Imaging and Sensing 2008 ; Conference date: 20-01-2008 Through 23-01-2008",
}