Slow reacting substance (SRS) from ionophore A23187-stimulated human leukemic basophils. I. Evidence for a precursor role of arachidonic acid and initial purification

L. D. Yecies; H. J. Wedner; C. W. Parker

Slow reacting substance (SRS) from ionophore A23187-stimulated human leukemic basophils. I. Evidence for a precursor role of arachidonic acid and initial purification

L. D. Yecies
, H. J. Wedner
, C. W. Parker

Research output: Contribution to journal › Article › peer-review

Abstract

SRS was generated from human leukemic basophils upon stimulation with ionophore A23187. Radiolabel from [¹⁴C]-AA was incorporated into SRS with continued comigration of radioactivity and bioactivity through several chromatographic systems including DEAE-cellulose, silicic acid, and RP-HPLC. Human basophilic leukemia SRS displayed physiochemical properties similar to those of rat basophilic leukemia cell SRS.

Original language	English
Pages (from-to)	2814-2816
Number of pages	3
Journal	Journal of Immunology
Volume	123
Issue number	6
State	Published - Dec 1 1979

Cite this

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title = "Slow reacting substance (SRS) from ionophore A23187-stimulated human leukemic basophils. I. Evidence for a precursor role of arachidonic acid and initial purification",

abstract = "SRS was generated from human leukemic basophils upon stimulation with ionophore A23187. Radiolabel from [14C]-AA was incorporated into SRS with continued comigration of radioactivity and bioactivity through several chromatographic systems including DEAE-cellulose, silicic acid, and RP-HPLC. Human basophilic leukemia SRS displayed physiochemical properties similar to those of rat basophilic leukemia cell SRS.",

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year = "1979",

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AU - Yecies, L. D.

AU - Wedner, H. J.

AU - Parker, C. W.

PY - 1979/12/1

Y1 - 1979/12/1

N2 - SRS was generated from human leukemic basophils upon stimulation with ionophore A23187. Radiolabel from [14C]-AA was incorporated into SRS with continued comigration of radioactivity and bioactivity through several chromatographic systems including DEAE-cellulose, silicic acid, and RP-HPLC. Human basophilic leukemia SRS displayed physiochemical properties similar to those of rat basophilic leukemia cell SRS.

AB - SRS was generated from human leukemic basophils upon stimulation with ionophore A23187. Radiolabel from [14C]-AA was incorporated into SRS with continued comigration of radioactivity and bioactivity through several chromatographic systems including DEAE-cellulose, silicic acid, and RP-HPLC. Human basophilic leukemia SRS displayed physiochemical properties similar to those of rat basophilic leukemia cell SRS.

UR - https://www.scopus.com/pages/publications/0018676120

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AN - SCOPUS:0018676120

SN - 0022-1767

VL - 123

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JO - Journal of Immunology

JF - Journal of Immunology

IS - 6

ER -

Slow reacting substance (SRS) from ionophore A23187-stimulated human leukemic basophils. I. Evidence for a precursor role of arachidonic acid and initial purification

Abstract

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