Slow reacting substance (SRS) from ionophore A23187-stimulated human leukemic basophils. I. Evidence for a precursor role of arachidonic acid and initial purification

L. D. Yecies, H. J. Wedner, C. W. Parker

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

SRS was generated from human leukemic basophils upon stimulation with ionophore A23187. Radiolabel from [14C]-AA was incorporated into SRS with continued comigration of radioactivity and bioactivity through several chromatographic systems including DEAE-cellulose, silicic acid, and RP-HPLC. Human basophilic leukemia SRS displayed physiochemical properties similar to those of rat basophilic leukemia cell SRS.

Original languageEnglish
Pages (from-to)2814-2816
Number of pages3
JournalJournal of Immunology
Volume123
Issue number6
StatePublished - Dec 1 1979

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