TY - JOUR
T1 - Slow inactivation of Na+ channels
AU - Silva, Jonathan
N1 - Publisher Copyright:
© Springer-Verlag Berlin Heidelberg 2014.
PY - 2014
Y1 - 2014
N2 - Prolonged depolarizing pulses that last seconds to minutes cause slow inactivation of Na+ channels, which regulates neuron and myocyte excitability by reducing availability of inward current. In neurons, slow inactivation has been linked to memory of previous excitation and in skeletal muscle it ensures myocytes are able to contract when K+ is elevated. The molecular mechanisms underlying slow inactivation are unclear even though it has been studied for 50+ years. This chapter reviews what is known to date regarding the definition, measurement, and mechanisms of voltage-gated Na+ channel slow inactivation.
AB - Prolonged depolarizing pulses that last seconds to minutes cause slow inactivation of Na+ channels, which regulates neuron and myocyte excitability by reducing availability of inward current. In neurons, slow inactivation has been linked to memory of previous excitation and in skeletal muscle it ensures myocytes are able to contract when K+ is elevated. The molecular mechanisms underlying slow inactivation are unclear even though it has been studied for 50+ years. This chapter reviews what is known to date regarding the definition, measurement, and mechanisms of voltage-gated Na+ channel slow inactivation.
KW - Fluorometry
KW - Hyperkalemic periodic paralysis
KW - Inactivation
UR - https://www.scopus.com/pages/publications/84903891745
U2 - 10.1007/978-3-642-41588-3_3
DO - 10.1007/978-3-642-41588-3_3
M3 - Article
C2 - 24737231
AN - SCOPUS:84903891745
SN - 0171-2004
VL - 221
SP - 33
EP - 49
JO - Handbook of Experimental Pharmacology
JF - Handbook of Experimental Pharmacology
ER -