SLO-2, a K+ channel with an unusual Cl- dependence

Alex Yuan, Michelle Dourado, Alice Butler, Nina Walton, Aguan Wei, Lawrence Salkoff

Research output: Contribution to journalArticlepeer-review

95 Scopus citations


The gating of different potassium channels depends on many diverse factors. We now report a unique example of a K+ channel with a Cl- dependence. The slo-2 gene was cloned from Caenorhabditis elegans and is widely expressed in both neurons and muscles; it was highly abundant, as suggested by its high representation in the C. elegans EST database. SLO-2, like its paralogue, SLO-1, was also dependent on Ca2+. We show by site- directed mutagenesis that its requirements for both Cl- and Ca2+ are synergistic and associated with the same functional domain. SLO-2's dependence on Cl- implies that intracellular Cl- homeostasis may be important in regulating cellular excitability through this unusual K+ channel.

Original languageEnglish
Pages (from-to)771-779
Number of pages9
JournalNature neuroscience
Issue number8
StatePublished - Aug 1 2000


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