Sliding set-points of immune responses for therapy of autoimmunity

Chyi Song Hsieh, Jhoanne Lynne Bautista

Research output: Contribution to journalShort surveypeer-review

5 Scopus citations

Abstract

Although recent developments in the treatment of autoimmune disease have dramatically improved patient outcomes, these medications are not curative. Two studies in this issue demonstrate the feasibility of curing spontaneous autoimmunity in animal models via short-term enhancement of naturally arising regulatory T (T reg) cells, a subset of CD4+ T cells needed for maintaining self-tolerance. Importantly, these therapies seemed to generate a new equilibrium, or "set-point," at which self-tissue damage no longer occurred long after the drug was eliminated from the body.

Original languageEnglish
Pages (from-to)1819-1823
Number of pages5
JournalJournal of Experimental Medicine
Volume207
Issue number9
DOIs
StatePublished - Aug 30 2010

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