TY - JOUR
T1 - Sleep Disturbances in Patients with Autoimmune Encephalitis
AU - Blattner, Margaret S.
AU - Day, Gregory S.
N1 - Funding Information:
Dr. GS Day is supported by the National Institutes of Health/National Institute on Aging (K23AG064029).
Publisher Copyright:
© 2020, Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2020/7/1
Y1 - 2020/7/1
N2 - Purpose of Review: To review sleep complaints reported in patients with autoimmune encephalitis, explore the relationship between sleep disturbances and subtypes of autoimmune encephalitis, and leverage knowledge concerning antibody-antigen specificity to inform the receptors, structures, and disseminated neural networks that contribute to sleep function in health and disease. Recent Findings: Autoimmune encephalitis is an inflammatory brain disorder characterized by the subacute onset of psychiatric symptoms, cognitive impairment, and focal neurologic deficits or seizures. Sleep disturbances are detected in a majority of patients systematically screened for sleep complaints, may be the presenting symptom in patients with autoimmune encephalitis, and may compromise recovery in patients with autoimmune encephalitis. Summary: Early recognition of specific sleep disturbances in patients with subacute changes in behavior or cognition may support the diagnosis of autoimmune encephalitis. Similarly, recognition and treatment of sleep dysfunction in patients with known autoimmune encephalitis may speed recovery and improve long-term outcomes.
AB - Purpose of Review: To review sleep complaints reported in patients with autoimmune encephalitis, explore the relationship between sleep disturbances and subtypes of autoimmune encephalitis, and leverage knowledge concerning antibody-antigen specificity to inform the receptors, structures, and disseminated neural networks that contribute to sleep function in health and disease. Recent Findings: Autoimmune encephalitis is an inflammatory brain disorder characterized by the subacute onset of psychiatric symptoms, cognitive impairment, and focal neurologic deficits or seizures. Sleep disturbances are detected in a majority of patients systematically screened for sleep complaints, may be the presenting symptom in patients with autoimmune encephalitis, and may compromise recovery in patients with autoimmune encephalitis. Summary: Early recognition of specific sleep disturbances in patients with subacute changes in behavior or cognition may support the diagnosis of autoimmune encephalitis. Similarly, recognition and treatment of sleep dysfunction in patients with known autoimmune encephalitis may speed recovery and improve long-term outcomes.
KW - Antibody-mediated encephalitis
KW - Autoimmune encephalitis
KW - Polysomnography
KW - Sleep dysfunction
UR - https://www.scopus.com/pages/publications/85086164046
U2 - 10.1007/s11910-020-01048-0
DO - 10.1007/s11910-020-01048-0
M3 - Review article
C2 - 32524504
AN - SCOPUS:85086164046
SN - 1528-4042
VL - 20
JO - Current neurology and neuroscience reports
JF - Current neurology and neuroscience reports
IS - 7
M1 - 28
ER -