TY - JOUR
T1 - Sleep Disturbance and SARS–CoV-2 Vaccinations in Patients With Chronic Inflammatory Disease
AU - Pawar, Niti
AU - Taylor, Kimberly E.
AU - Yang, Monica
AU - Deepak, Parakkal
AU - Kim, Wooseob
AU - Paley, Michael A.
AU - Matloubian, Mehrdad
AU - Carvidi, Alex
AU - Ciorba, Matthew A.
AU - Demissie, Emanuel
AU - El-Qunni, Alia
AU - Huang, Katherine
AU - Kinnett, Baylee
AU - McMorrow, Lily E.
AU - Paez, Diana
AU - Poole, Mackenzie
AU - Rose, Abigail
AU - Schriefer, Rebecca E.
AU - Kim, Alfred H.J.
AU - Nakamura, Mary
AU - Katz, Patricia
AU - Gensler, Lianne S.
N1 - Publisher Copyright:
© 2022 American College of Rheumatology.
PY - 2023/8
Y1 - 2023/8
N2 - Objective: Immunocompromised patients with chronic inflammatory disease (CID) may have experienced additional psychosocial burden during the COVID-19 pandemic due to their immunocompromised status. This study was undertaken to determine if vaccination would result in improved patient-reported outcomes longitudinally among individuals with CID undergoing SARS–CoV-2 vaccination regardless of baseline anxiety. Methods: Data are from a cohort of individuals with CID from 2 sites who underwent SARS–CoV-2 vaccination. Participants completed 3 study visits before and after 2 messenger RNA vaccine doses in the initial vaccination series when clinical data were collected. Patient-reported outcomes were measured using the Patient-Reported Outcomes Measurement Information System 29-item Health Profile and expressed as T scores, with 2 groups stratified by high and low baseline anxiety. Mixed-effects models were used to examine longitudinal changes, adjusting for age, sex, and study site. Results: A total of 72% of the cohort was female with a mean ± SD age of 48.1 ± 15.5 years. Overall, sleep disturbance improved following both doses of SARS–CoV-2 vaccinations, and anxiety decreased after the second dose. Physical function scores worsened but did not meet the minimally important difference threshold. When stratifying by baseline anxiety, improvement in anxiety, fatigue, and social participation were greater in the high anxiety group. Physical function worsened slightly in both groups, and sleep disturbance improved significantly in the high anxiety group. Conclusion: Sleep disturbance decreased in a significant and meaningful way in patients with CID upon vaccination. In patients with higher baseline anxiety, social participation increased, and anxiety, fatigue, and sleep disturbance decreased. Overall, results suggest that SARS–CoV-2 vaccination may improve mental health and well-being, particularly among those with greater anxiety.
AB - Objective: Immunocompromised patients with chronic inflammatory disease (CID) may have experienced additional psychosocial burden during the COVID-19 pandemic due to their immunocompromised status. This study was undertaken to determine if vaccination would result in improved patient-reported outcomes longitudinally among individuals with CID undergoing SARS–CoV-2 vaccination regardless of baseline anxiety. Methods: Data are from a cohort of individuals with CID from 2 sites who underwent SARS–CoV-2 vaccination. Participants completed 3 study visits before and after 2 messenger RNA vaccine doses in the initial vaccination series when clinical data were collected. Patient-reported outcomes were measured using the Patient-Reported Outcomes Measurement Information System 29-item Health Profile and expressed as T scores, with 2 groups stratified by high and low baseline anxiety. Mixed-effects models were used to examine longitudinal changes, adjusting for age, sex, and study site. Results: A total of 72% of the cohort was female with a mean ± SD age of 48.1 ± 15.5 years. Overall, sleep disturbance improved following both doses of SARS–CoV-2 vaccinations, and anxiety decreased after the second dose. Physical function scores worsened but did not meet the minimally important difference threshold. When stratifying by baseline anxiety, improvement in anxiety, fatigue, and social participation were greater in the high anxiety group. Physical function worsened slightly in both groups, and sleep disturbance improved significantly in the high anxiety group. Conclusion: Sleep disturbance decreased in a significant and meaningful way in patients with CID upon vaccination. In patients with higher baseline anxiety, social participation increased, and anxiety, fatigue, and sleep disturbance decreased. Overall, results suggest that SARS–CoV-2 vaccination may improve mental health and well-being, particularly among those with greater anxiety.
UR - http://www.scopus.com/inward/record.url?scp=85147994446&partnerID=8YFLogxK
U2 - 10.1002/acr.25065
DO - 10.1002/acr.25065
M3 - Article
C2 - 36479599
AN - SCOPUS:85147994446
SN - 2151-464X
VL - 75
SP - 1849
EP - 1856
JO - Arthritis Care and Research
JF - Arthritis Care and Research
IS - 8
ER -