TY - JOUR
T1 - Sleep Disorders in Human Prionopathies
AU - Blattner, Margaret
AU - de Bruin, Gabriela Sales
N1 - Publisher Copyright:
© 2017, Springer International Publishing AG.
PY - 2017/9/1
Y1 - 2017/9/1
N2 - Purpose of Review: Sleep disorders are common in human prionopathies, such as sporadic Creutzfeldt-Jakob disease and fatal familial insomnia, and often manifest early in the disease course. Recent Findings: Clinical manifestations of sleep pathology in these disorders are variable and include insomnia, sleep disordered breathing, rapid eye movement sleep behavior disorder, and hypersomnia, all of which likely result from the rapid neurodegeneration of anatomic structures critical to sleep physiology. Summary: Given their high prevalence in human prionopathies, sleep disorders/disturbances may be of diagnostic utility and/or serve as potential biomarkers of human prion disease, and a thorough screen for sleep disturbances should be performed by all clinicians evaluating patients with rapidly progressive dementias. While limited data exists on the subject, treatment of sleep disturbances in patients with prion disease may improve quality of life, for both patients and caretakers.
AB - Purpose of Review: Sleep disorders are common in human prionopathies, such as sporadic Creutzfeldt-Jakob disease and fatal familial insomnia, and often manifest early in the disease course. Recent Findings: Clinical manifestations of sleep pathology in these disorders are variable and include insomnia, sleep disordered breathing, rapid eye movement sleep behavior disorder, and hypersomnia, all of which likely result from the rapid neurodegeneration of anatomic structures critical to sleep physiology. Summary: Given their high prevalence in human prionopathies, sleep disorders/disturbances may be of diagnostic utility and/or serve as potential biomarkers of human prion disease, and a thorough screen for sleep disturbances should be performed by all clinicians evaluating patients with rapidly progressive dementias. While limited data exists on the subject, treatment of sleep disturbances in patients with prion disease may improve quality of life, for both patients and caretakers.
KW - Creutzfeldt-Jakob disease
KW - Fatal familial insomnia
KW - Neurodegenerative disease
KW - Prion
KW - Sleep disorders
UR - http://www.scopus.com/inward/record.url?scp=85086153024&partnerID=8YFLogxK
U2 - 10.1007/s40675-017-0087-y
DO - 10.1007/s40675-017-0087-y
M3 - Review article
AN - SCOPUS:85086153024
SN - 2198-6401
VL - 3
SP - 215
EP - 221
JO - Current Sleep Medicine Reports
JF - Current Sleep Medicine Reports
IS - 3
ER -