TY - JOUR
T1 - Sleep and Alzheimer disease pathology-a bidirectional relationship
AU - Ju, Yo El S.
AU - Lucey, Brendan P.
AU - Holtzman, David M.
PY - 2014/2
Y1 - 2014/2
N2 - Factors other than age and genetics may increase the risk of developing Alzheimer disease (AD). Accumulation of the amyloid-β (Aβ) peptide in the brain seems to initiate a cascade of key events in the pathogenesis of AD. Moreover, evidence is emerging that the sleep-wake cycle directly influences levels of Aβ in the brain. In experimental models, sleep deprivation increases the concentration of soluble Aβ and results in chronic accumulation of Aβ, whereas sleep extension has the opposite effect. Furthermore, once Aβ accumulates, increased wakefulness and altered sleep patterns develop. Individuals with early Aβ deposition who still have normal cognitive function report sleep abnormalities, as do individuals with very mild dementia due to AD. Thus, sleep and neurodegenerative disease may influence each other in many ways that have important implications for the diagnosis and treatment of AD.
AB - Factors other than age and genetics may increase the risk of developing Alzheimer disease (AD). Accumulation of the amyloid-β (Aβ) peptide in the brain seems to initiate a cascade of key events in the pathogenesis of AD. Moreover, evidence is emerging that the sleep-wake cycle directly influences levels of Aβ in the brain. In experimental models, sleep deprivation increases the concentration of soluble Aβ and results in chronic accumulation of Aβ, whereas sleep extension has the opposite effect. Furthermore, once Aβ accumulates, increased wakefulness and altered sleep patterns develop. Individuals with early Aβ deposition who still have normal cognitive function report sleep abnormalities, as do individuals with very mild dementia due to AD. Thus, sleep and neurodegenerative disease may influence each other in many ways that have important implications for the diagnosis and treatment of AD.
UR - http://www.scopus.com/inward/record.url?scp=84893829393&partnerID=8YFLogxK
U2 - 10.1038/nrneurol.2013.269
DO - 10.1038/nrneurol.2013.269
M3 - Review article
C2 - 24366271
AN - SCOPUS:84893829393
SN - 1759-4758
VL - 10
SP - 115
EP - 119
JO - Nature Reviews Neurology
JF - Nature Reviews Neurology
IS - 2
ER -