Skull bone marrow channels as immune gateways to the central nervous system

Jose A. Mazzitelli, Fadi E. Pulous, Leon C.D. Smyth, Zeynep Kaya, Justin Rustenhoven, Michael A. Moskowitz, Jonathan Kipnis, Matthias Nahrendorf

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Decades of research have characterized diverse immune cells surveilling the CNS. More recently, the discovery of osseous channels (so-called ‘skull channels’) connecting the meninges with the skull and vertebral bone marrow has revealed a new layer of complexity in our understanding of neuroimmune interactions. Here we discuss our current understanding of skull and vertebral bone marrow anatomy, its contribution of leukocytes to the meninges, and its surveillance of the CNS. We explore the role of this hematopoietic output on CNS health, focusing on the supply of immune cells during health and disease.

Original languageEnglish
Pages (from-to)2052-2062
Number of pages11
JournalNature neuroscience
Volume26
Issue number12
DOIs
StatePublished - Dec 2023

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