TY - JOUR
T1 - Skull bone marrow channels as immune gateways to the central nervous system
AU - Mazzitelli, Jose A.
AU - Pulous, Fadi E.
AU - Smyth, Leon C.D.
AU - Kaya, Zeynep
AU - Rustenhoven, Justin
AU - Moskowitz, Michael A.
AU - Kipnis, Jonathan
AU - Nahrendorf, Matthias
N1 - Publisher Copyright:
© 2023, Springer Nature America, Inc.
PY - 2023/12
Y1 - 2023/12
N2 - Decades of research have characterized diverse immune cells surveilling the CNS. More recently, the discovery of osseous channels (so-called ‘skull channels’) connecting the meninges with the skull and vertebral bone marrow has revealed a new layer of complexity in our understanding of neuroimmune interactions. Here we discuss our current understanding of skull and vertebral bone marrow anatomy, its contribution of leukocytes to the meninges, and its surveillance of the CNS. We explore the role of this hematopoietic output on CNS health, focusing on the supply of immune cells during health and disease.
AB - Decades of research have characterized diverse immune cells surveilling the CNS. More recently, the discovery of osseous channels (so-called ‘skull channels’) connecting the meninges with the skull and vertebral bone marrow has revealed a new layer of complexity in our understanding of neuroimmune interactions. Here we discuss our current understanding of skull and vertebral bone marrow anatomy, its contribution of leukocytes to the meninges, and its surveillance of the CNS. We explore the role of this hematopoietic output on CNS health, focusing on the supply of immune cells during health and disease.
UR - http://www.scopus.com/inward/record.url?scp=85177682594&partnerID=8YFLogxK
U2 - 10.1038/s41593-023-01487-1
DO - 10.1038/s41593-023-01487-1
M3 - Article
C2 - 37996526
AN - SCOPUS:85177682594
SN - 1097-6256
VL - 26
SP - 2052
EP - 2062
JO - Nature neuroscience
JF - Nature neuroscience
IS - 12
ER -