Skeletal effects of whole-body vibration in adult and aged mice

Michelle A. Lynch, Michael D. Brodt, Matthew J. Silva

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

Low-amplitude, whole-body vibration (WBV) may be anabolic for bone. Animal studies of WBV have not evaluated skeletal effects in aged animals.Weexposed 75 male BALB/c mice (7 month/young-adult; 22 month/aged) to 5 weeks of dailyWBV(15 min/day, 5 day/ wk; 90 Hz sine wave) at acceleration amplitudes of 0 (sham), 0.3, or 1.0 g. Whole-body bone mineral content (BMC) increased with time in 7 month ( p<0.001) but not 22 month ( p = 0.34) mice, independent ofWBV( p = 0.60). In 7 month mice, lower-legBMCincreased with time in 0.3 and 1.0 g groups (p < 0.05). but not in the sham group ( p = 0.09), indicating a positive WBV effect. In 22 month mice, there were no changes with time in lower-leg BMC ( p = 0.11). WBV did not affect tibial trabecular or cortical bone structure (by μCT), dynamic indices of trabecular or cortical bone formation, trabecular osteoclast surface, or the mass of the reproductive fat pad ( p>0.05). Each of these outcomes was diminished in 7 month versus 22 month animals ( p<0.05). In summary, 5 weeks of daily exposure to low-amplitudeWBVhad no skeletal effects in aged male mice. The potential of WBV to enhance bone mass in age-related osteoporosis is not supported in this preclinical study.

Original languageEnglish
Pages (from-to)241-247
Number of pages7
JournalJournal of Orthopaedic Research
Volume28
Issue number2
DOIs
StatePublished - Feb 1 2010

Keywords

  • Age-related osteoporosis
  • Bone density
  • Bone formation
  • Mouse
  • Whole-body vibration

Fingerprint Dive into the research topics of 'Skeletal effects of whole-body vibration in adult and aged mice'. Together they form a unique fingerprint.

  • Cite this