SIX2 Regulates Human β Cell Differentiation from Stem Cells and Functional Maturation In Vitro

Leonardo Velazco-Cruz, Madeleine M. Goedegebuure, Kristina G. Maxwell, Punn Augsornworawat, Nathaniel J. Hogrebe, Jeffrey R. Millman

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Velazco-Cruz et al. characterize the role of SIX2 in stem cell differentiation to β cells. SIX2 expression is restricted to late-stage endocrine cells. Generation of β cells does not require SIX2, but lack of SIX2 impairs maturation, as assessed by glucose-stimulated insulin secretion, calcium flux, mitochondrial respiration, and gene expression.

Original languageEnglish
Article number107687
JournalCell Reports
Volume31
Issue number8
DOIs
StatePublished - May 26 2020

Keywords

  • SIX2
  • beta cells
  • diabetes
  • differentiation
  • insulin
  • islets
  • pluripotent stem cells
  • stem cells

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