TY - JOUR
T1 - SIX2 Regulates Human β Cell Differentiation from Stem Cells and Functional Maturation In Vitro
AU - Velazco-Cruz, Leonardo
AU - Goedegebuure, Madeleine M.
AU - Maxwell, Kristina G.
AU - Augsornworawat, Punn
AU - Hogrebe, Nathaniel J.
AU - Millman, Jeffrey R.
N1 - Publisher Copyright:
© 2020 The Author(s)
PY - 2020/5/26
Y1 - 2020/5/26
N2 - Velazco-Cruz et al. characterize the role of SIX2 in stem cell differentiation to β cells. SIX2 expression is restricted to late-stage endocrine cells. Generation of β cells does not require SIX2, but lack of SIX2 impairs maturation, as assessed by glucose-stimulated insulin secretion, calcium flux, mitochondrial respiration, and gene expression.
AB - Velazco-Cruz et al. characterize the role of SIX2 in stem cell differentiation to β cells. SIX2 expression is restricted to late-stage endocrine cells. Generation of β cells does not require SIX2, but lack of SIX2 impairs maturation, as assessed by glucose-stimulated insulin secretion, calcium flux, mitochondrial respiration, and gene expression.
KW - SIX2
KW - beta cells
KW - diabetes
KW - differentiation
KW - insulin
KW - islets
KW - pluripotent stem cells
KW - stem cells
UR - http://www.scopus.com/inward/record.url?scp=85085348084&partnerID=8YFLogxK
U2 - 10.1016/j.celrep.2020.107687
DO - 10.1016/j.celrep.2020.107687
M3 - Article
C2 - 32460030
AN - SCOPUS:85085348084
SN - 2211-1247
VL - 31
JO - Cell Reports
JF - Cell Reports
IS - 8
M1 - 107687
ER -