TY - JOUR
T1 - Site-targeted acoustic contrast agent detects molecular expression of tissue factor after balloon angioplasty
AU - Hall, Christopher S.
AU - Abendschein, Dana R.
AU - Scherrer, David E.
AU - Scott, Michael J.
AU - Marsh, Jon N.
AU - Wickline, Samuel A.
AU - Lanza, Gregory M.
N1 - Copyright:
Copyright 2004 Elsevier Science B.V., Amsterdam. All rights reserved.
PY - 2000
Y1 - 2000
N2 - The concept of molecular imaging and localization of carotid arteries' tissue factor in vivo using a new, nanoparticulate emulsion is demonstrated. The enhancement of the visualization of the molecular expression of tissue factor could prove to be a prognostically important predictor of subsequent restenosis. Moreover, with the incorporation of specific drug treatments into the nanoparticulate contrast agent, ultrasonic molecular imaging may yield reliable detection and quantification of nascent pathologies and facilitate targeted drug therapy.
AB - The concept of molecular imaging and localization of carotid arteries' tissue factor in vivo using a new, nanoparticulate emulsion is demonstrated. The enhancement of the visualization of the molecular expression of tissue factor could prove to be a prognostically important predictor of subsequent restenosis. Moreover, with the incorporation of specific drug treatments into the nanoparticulate contrast agent, ultrasonic molecular imaging may yield reliable detection and quantification of nascent pathologies and facilitate targeted drug therapy.
UR - http://www.scopus.com/inward/record.url?scp=0033737633&partnerID=8YFLogxK
M3 - Conference article
AN - SCOPUS:0033737633
SN - 0277-786X
VL - 3982
SP - 325
EP - 332
JO - Proceedings of SPIE - The International Society for Optical Engineering
JF - Proceedings of SPIE - The International Society for Optical Engineering
T2 - Medical Imaging 2000: Ultrasonic Imaging and Signal Processing
Y2 - 16 February 2000 through 17 February 2000
ER -