Site-selective, cleavable linkers: Quality control and the characterization of small molecules on microelectrode arrays

Bo Bi; Richard Y.C. Huang; Karl Maurer; Ceng Chen; Kevin D. Moeller

doi:10.1021/jo2017907

Site-selective, cleavable linkers: Quality control and the characterization of small molecules on microelectrode arrays

Bo Bi, Richard Y.C. Huang, Karl Maurer, Ceng Chen, Kevin D. Moeller

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

A "safety-catch" linker strategy has been used to release a portion of the products of a Diels-Alder reaction conducted on a microelectrode array for characterization of stereochemistry. The attachment and cleavage of organic compounds from the surface of selected electrodes in the array can be accomplished by site-selective generation of base or acid at the electrode. It was found that the surface of the array had a minor influence on the stereochemistry of the Diels-Alder reaction, leading to slightly more of the exo-product relative to a similar solution-phase reaction.

Original language	English
Pages (from-to)	9053-9059
Number of pages	7
Journal	Journal of Organic Chemistry
Volume	76
Issue number	21
DOIs	https://doi.org/10.1021/jo2017907
State	Published - Nov 4 2011

Access to Document

10.1021/jo2017907

Cite this

@article{c27a9a356d27462b92bf64e791286734,

title = "Site-selective, cleavable linkers: Quality control and the characterization of small molecules on microelectrode arrays",

abstract = "A {"}safety-catch{"} linker strategy has been used to release a portion of the products of a Diels-Alder reaction conducted on a microelectrode array for characterization of stereochemistry. The attachment and cleavage of organic compounds from the surface of selected electrodes in the array can be accomplished by site-selective generation of base or acid at the electrode. It was found that the surface of the array had a minor influence on the stereochemistry of the Diels-Alder reaction, leading to slightly more of the exo-product relative to a similar solution-phase reaction.",

author = "Bo Bi and Huang, {Richard Y.C.} and Karl Maurer and Ceng Chen and Moeller, {Kevin D.}",

year = "2011",

month = nov,

day = "4",

doi = "10.1021/jo2017907",

language = "English",

volume = "76",

pages = "9053--9059",

journal = "Journal of Organic Chemistry",

issn = "0022-3263",

number = "21",

}

TY - JOUR

T1 - Site-selective, cleavable linkers

T2 - Quality control and the characterization of small molecules on microelectrode arrays

AU - Bi, Bo

AU - Huang, Richard Y.C.

AU - Maurer, Karl

AU - Chen, Ceng

AU - Moeller, Kevin D.

PY - 2011/11/4

Y1 - 2011/11/4

N2 - A "safety-catch" linker strategy has been used to release a portion of the products of a Diels-Alder reaction conducted on a microelectrode array for characterization of stereochemistry. The attachment and cleavage of organic compounds from the surface of selected electrodes in the array can be accomplished by site-selective generation of base or acid at the electrode. It was found that the surface of the array had a minor influence on the stereochemistry of the Diels-Alder reaction, leading to slightly more of the exo-product relative to a similar solution-phase reaction.

AB - A "safety-catch" linker strategy has been used to release a portion of the products of a Diels-Alder reaction conducted on a microelectrode array for characterization of stereochemistry. The attachment and cleavage of organic compounds from the surface of selected electrodes in the array can be accomplished by site-selective generation of base or acid at the electrode. It was found that the surface of the array had a minor influence on the stereochemistry of the Diels-Alder reaction, leading to slightly more of the exo-product relative to a similar solution-phase reaction.

UR - http://www.scopus.com/inward/record.url?scp=80055068382&partnerID=8YFLogxK

U2 - 10.1021/jo2017907

DO - 10.1021/jo2017907

M3 - Article

C2 - 21958106

AN - SCOPUS:80055068382

SN - 0022-3263

VL - 76

SP - 9053

EP - 9059

JO - Journal of Organic Chemistry

JF - Journal of Organic Chemistry

IS - 21

ER -

Site-selective, cleavable linkers: Quality control and the characterization of small molecules on microelectrode arrays

Abstract

Access to Document

Other files and links

Fingerprint

Cite this