TY - JOUR
T1 - Site of action of anorectic drugs
T2 - Glucoprivic- versus food deprivation-induced feeding
AU - Angel, Itzchak
AU - Stivers, Jill A.
AU - Paul, Steven M.
AU - Crawley, Jacqueline N.
PY - 1987/6
Y1 - 1987/6
N2 - Feeding induced by 2-deoxyglucose was compared with feeding induced by food deprivation in terms of antagonism by anorectic drugs and of anatomical site of action. Glucoprivic feeding was completely blocked by microinjection of amphetamine, fenfluramine, and mazindol into the paraventricular nucleus of the hypothalamus (PVN). Deprivation-induced feeding was not blocked by amphetamine, fenfluramine, or mazindol microinjected into the PVN. Neither the feeding induced by 2-deoxyglucose nor its reversal by amphetamine were blocked by pretreatment with the β-adrenergic antagonist, propranolol. Amphetamine and fenfluramine blocked both glucoprivic- and deprivation-induced feeding when microinjected into the perifornical region of the lateral hypothalamus. These data suggest that food consumption induced by 2-deoxyglucose treatment can be antagonized by anorectic drugs acting at recognition sites present in several hypothalamic nuclei, while deprivation-induced feeding acts through different receptor mechanisms which may be specific to the perifornical region of the lateral hypothalamus.
AB - Feeding induced by 2-deoxyglucose was compared with feeding induced by food deprivation in terms of antagonism by anorectic drugs and of anatomical site of action. Glucoprivic feeding was completely blocked by microinjection of amphetamine, fenfluramine, and mazindol into the paraventricular nucleus of the hypothalamus (PVN). Deprivation-induced feeding was not blocked by amphetamine, fenfluramine, or mazindol microinjected into the PVN. Neither the feeding induced by 2-deoxyglucose nor its reversal by amphetamine were blocked by pretreatment with the β-adrenergic antagonist, propranolol. Amphetamine and fenfluramine blocked both glucoprivic- and deprivation-induced feeding when microinjected into the perifornical region of the lateral hypothalamus. These data suggest that food consumption induced by 2-deoxyglucose treatment can be antagonized by anorectic drugs acting at recognition sites present in several hypothalamic nuclei, while deprivation-induced feeding acts through different receptor mechanisms which may be specific to the perifornical region of the lateral hypothalamus.
KW - 2-Deoxy-D-glucose
KW - Amphetamine
KW - Anorectic drugs
KW - Glucoprivic feeding
KW - Hypothalamus
KW - Paraventricular hypothalamic nucleus
UR - http://www.scopus.com/inward/record.url?scp=0023204094&partnerID=8YFLogxK
U2 - 10.1016/0091-3057(87)90572-7
DO - 10.1016/0091-3057(87)90572-7
M3 - Article
C2 - 3628443
AN - SCOPUS:0023204094
SN - 0091-3057
VL - 27
SP - 291
EP - 297
JO - Pharmacology, Biochemistry and Behavior
JF - Pharmacology, Biochemistry and Behavior
IS - 2
ER -