TY - JOUR
T1 - Sirtuin 6 and renal injury
T2 - another link in the β-catenin chain?
AU - Gewin, Leslie S.
N1 - Funding Information:
This work was supported by the Veterans Affairs Merit 1I01BX003425-01A21 (to LG) and the National Institute of Diabetes and Digestive and Kidney Diseases R01DK108968-01 (to LG).
Funding Information:
This work was supported by the Veterans Affairs Merit 1I01BX003425-01A21 (to LG) and the National Institute of Diabetes and Digestive and Kidney Diseases R01DK108968-01 (to LG).
Publisher Copyright:
© 2019 International Society of Nephrology
PY - 2020/1
Y1 - 2020/1
N2 - A protective role for sirtuin 6 (Sirt6) in the context of chronic renal injury is reported by Cai et al. in this issue of Kidney International. The mechanism is thought to be mediated by Sirt6’s deacetylase activity, specifically on β-catenin target genes. This commentary discusses these results and the interaction between Sirt6 and β-catenin within the broader context of β-catenin signaling and injury.
AB - A protective role for sirtuin 6 (Sirt6) in the context of chronic renal injury is reported by Cai et al. in this issue of Kidney International. The mechanism is thought to be mediated by Sirt6’s deacetylase activity, specifically on β-catenin target genes. This commentary discusses these results and the interaction between Sirt6 and β-catenin within the broader context of β-catenin signaling and injury.
UR - http://www.scopus.com/inward/record.url?scp=85076476324&partnerID=8YFLogxK
U2 - 10.1016/j.kint.2019.09.022
DO - 10.1016/j.kint.2019.09.022
M3 - Comment/debate
C2 - 31901350
AN - SCOPUS:85076476324
SN - 0085-2538
VL - 97
SP - 24
EP - 27
JO - Kidney International
JF - Kidney International
IS - 1
ER -