Sirtuin 6 and renal injury: another link in the β-catenin chain?

Research output: Contribution to journalComment/debate

3 Scopus citations

Abstract

A protective role for sirtuin 6 (Sirt6) in the context of chronic renal injury is reported by Cai et al. in this issue of Kidney International. The mechanism is thought to be mediated by Sirt6’s deacetylase activity, specifically on β-catenin target genes. This commentary discusses these results and the interaction between Sirt6 and β-catenin within the broader context of β-catenin signaling and injury.

Original languageEnglish
Pages (from-to)24-27
Number of pages4
JournalKidney International
Volume97
Issue number1
DOIs
StatePublished - Jan 2020

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