TY - JOUR
T1 - Sirt1 as a key regulator orchestrating the response to caloric restriction
AU - Moynihan, Kathryn A.
AU - Imai, Shin ichiro
N1 - Funding Information:
We thank Andrew Grimm and all other members of the Imai lab for their helpful discussions and comments. We also thank David Ramsey for his comments. We apologize to those whose work is not cited owing to space limitations. K.A.M. is a fellow supported by the Lucille P. Markey Special Emphasis Pathway in Human Pathology and the Glenn/AFAR Scholarship for Research in the Biology of Aging. S.I. is an Ellison Medical Foundation Scholar in Aging. This work was supported by a grant from NIA (AG024150) to S.I.
PY - 2006
Y1 - 2006
N2 - Although it was discovered more than 70 years ago that caloric restriction (CR) extends the life span of rodents, the molecular basis of CR has remained obscure. Recently, NAD-dependent Sir2 deacetylases have emerged as key regulators that mediate the adaptive response to CR. Here, we describe the tissue-dependent functions of the mammalian Sir2 ortholog, Sirt1/Sir2α and present a molecular framework in which Sirt1 orchestrates multiple physiological changes into a coordinated response to CR in mammals.
AB - Although it was discovered more than 70 years ago that caloric restriction (CR) extends the life span of rodents, the molecular basis of CR has remained obscure. Recently, NAD-dependent Sir2 deacetylases have emerged as key regulators that mediate the adaptive response to CR. Here, we describe the tissue-dependent functions of the mammalian Sir2 ortholog, Sirt1/Sir2α and present a molecular framework in which Sirt1 orchestrates multiple physiological changes into a coordinated response to CR in mammals.
UR - https://www.scopus.com/pages/publications/33745879157
U2 - 10.1016/j.ddmec.2006.02.005
DO - 10.1016/j.ddmec.2006.02.005
M3 - Review article
AN - SCOPUS:33745879157
SN - 1740-6765
VL - 3
SP - 11
EP - 17
JO - Drug Discovery Today: Disease Mechanisms
JF - Drug Discovery Today: Disease Mechanisms
IS - 1
ER -