Single Photon Emission Computed Tomography and Positron Emission Tomography Imaging of Multi-drug Resistant P-glycoprotein-Monitoring a Transport Activity Important in Cancer, Blood-Brain Barrier Function and Alzheimer's Disease

David Piwnica-Worms, Aparna H. Kesarwala, Andrea Pichler, Julie L. Prior, Vijay Sharma

Research output: Contribution to journalReview article

19 Scopus citations

Abstract

Several radiopharmaceuticals enable SPECT and PET monitoring of Pgp-mediated transport activity in tissues in vivo. There is significant promise for noninvasive assessment of Pgp to guide choices of chemotherapy regimens, monitor MDR gene therapy, and assess a potential risk factor for development of AD at the level of the BBB.

Original languageEnglish
Pages (from-to)575-589
Number of pages15
JournalNeuroimaging Clinics of North America
Volume16
Issue number4
DOIs
StatePublished - Nov 1 2006

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