TY - JOUR
T1 - Single Photon Emission Computed Tomography and Positron Emission Tomography Imaging of Multi-drug Resistant P-glycoprotein-Monitoring a Transport Activity Important in Cancer, Blood-Brain Barrier Function and Alzheimer's Disease
AU - Piwnica-Worms, David
AU - Kesarwala, Aparna H.
AU - Pichler, Andrea
AU - Prior, Julie L.
AU - Sharma, Vijay
N1 - Funding Information:
This educational project was funded by the NIH Molecular Imaging Center grant P50 CA94056 and DOE contract DE FG02 94ER61885.
PY - 2006/11
Y1 - 2006/11
N2 - Several radiopharmaceuticals enable SPECT and PET monitoring of Pgp-mediated transport activity in tissues in vivo. There is significant promise for noninvasive assessment of Pgp to guide choices of chemotherapy regimens, monitor MDR gene therapy, and assess a potential risk factor for development of AD at the level of the BBB.
AB - Several radiopharmaceuticals enable SPECT and PET monitoring of Pgp-mediated transport activity in tissues in vivo. There is significant promise for noninvasive assessment of Pgp to guide choices of chemotherapy regimens, monitor MDR gene therapy, and assess a potential risk factor for development of AD at the level of the BBB.
UR - http://www.scopus.com/inward/record.url?scp=34447342432&partnerID=8YFLogxK
U2 - 10.1016/j.nic.2006.06.007
DO - 10.1016/j.nic.2006.06.007
M3 - Review article
C2 - 17148020
AN - SCOPUS:34447342432
SN - 1052-5149
VL - 16
SP - 575
EP - 589
JO - Neuroimaging Clinics of North America
JF - Neuroimaging Clinics of North America
IS - 4
ER -