Single-neuron datasets for linguistic and semantic processing in the human amygdala and hippocampus

Yue Wang; Runnan Cao; Jon T. Willie; Peter Brunner; Shuo Wang

doi:10.1038/s41597-025-05839-3

Single-neuron datasets for linguistic and semantic processing in the human amygdala and hippocampus

Yue Wang
, Runnan Cao
, Jon T. Willie
, Peter Brunner
, Shuo Wang

Research output: Contribution to journal › Article › peer-review

Abstract

Understanding linguistic and semantic processing in the human brain involves exploring intricate neural networks. However, it remains unclear whether and how the amygdala and hippocampus are involved in these processes. Here, we recorded single-neuron activity from the human amygdala and hippocampus while neurosurgical patients with intractable epilepsy performed various language tasks. Specifically, we recorded from 68 neurons in 7 patients for the visual language localizer task, 115 neurons in 12 patients for the auditory language localizer task, 88 neurons in 9 patients for the TIMIT task, and 51 neurons in 4 patients for the natural story task. Together, our comprehensive dataset with a considerable population of neurons can facilitate multifaceted investigation of language and semantic processing with the highest spatial and temporal resolution currently available in humans.

Original language	English
Article number	1482
Journal	Scientific data
Volume	12
Issue number	1
DOIs	https://doi.org/10.1038/s41597-025-05839-3
State	Published - Dec 2025

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title = "Single-neuron datasets for linguistic and semantic processing in the human amygdala and hippocampus",

abstract = "Understanding linguistic and semantic processing in the human brain involves exploring intricate neural networks. However, it remains unclear whether and how the amygdala and hippocampus are involved in these processes. Here, we recorded single-neuron activity from the human amygdala and hippocampus while neurosurgical patients with intractable epilepsy performed various language tasks. Specifically, we recorded from 68 neurons in 7 patients for the visual language localizer task, 115 neurons in 12 patients for the auditory language localizer task, 88 neurons in 9 patients for the TIMIT task, and 51 neurons in 4 patients for the natural story task. Together, our comprehensive dataset with a considerable population of neurons can facilitate multifaceted investigation of language and semantic processing with the highest spatial and temporal resolution currently available in humans.",

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N1 - Publisher Copyright: © The Author(s) 2025.

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N2 - Understanding linguistic and semantic processing in the human brain involves exploring intricate neural networks. However, it remains unclear whether and how the amygdala and hippocampus are involved in these processes. Here, we recorded single-neuron activity from the human amygdala and hippocampus while neurosurgical patients with intractable epilepsy performed various language tasks. Specifically, we recorded from 68 neurons in 7 patients for the visual language localizer task, 115 neurons in 12 patients for the auditory language localizer task, 88 neurons in 9 patients for the TIMIT task, and 51 neurons in 4 patients for the natural story task. Together, our comprehensive dataset with a considerable population of neurons can facilitate multifaceted investigation of language and semantic processing with the highest spatial and temporal resolution currently available in humans.

AB - Understanding linguistic and semantic processing in the human brain involves exploring intricate neural networks. However, it remains unclear whether and how the amygdala and hippocampus are involved in these processes. Here, we recorded single-neuron activity from the human amygdala and hippocampus while neurosurgical patients with intractable epilepsy performed various language tasks. Specifically, we recorded from 68 neurons in 7 patients for the visual language localizer task, 115 neurons in 12 patients for the auditory language localizer task, 88 neurons in 9 patients for the TIMIT task, and 51 neurons in 4 patients for the natural story task. Together, our comprehensive dataset with a considerable population of neurons can facilitate multifaceted investigation of language and semantic processing with the highest spatial and temporal resolution currently available in humans.

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Single-neuron datasets for linguistic and semantic processing in the human amygdala and hippocampus

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