Abstract
Augsornworawat et al. demonstrate that in vitro human stem-cell-derived islets have immature transcriptome profiles when compared to native human islets. After transplantation, immature SC-islet cells undergo drastic changes in transcriptome and acquire mature gene expression. Grafted SC-β cells express mature β cell genes, including MAFA and G6PC2, resembling native human islets.
Original language | English |
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Article number | 108067 |
Journal | Cell Reports |
Volume | 32 |
Issue number | 8 |
DOIs | |
State | Published - Aug 25 2020 |
Keywords
- IAPP
- alpha cells
- beta cells
- diabetes
- insulin
- islets
- sngle-cell RNA sequencing
- stem cells
- transcriptome