Single-Cell Transcriptome Profiling Reveals β Cell Maturation in Stem Cell-Derived Islets after Transplantation

Punn Augsornworawat, Kristina G. Maxwell, Leonardo Velazco-Cruz, Jeffrey R. Millman

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Augsornworawat et al. demonstrate that in vitro human stem-cell-derived islets have immature transcriptome profiles when compared to native human islets. After transplantation, immature SC-islet cells undergo drastic changes in transcriptome and acquire mature gene expression. Grafted SC-β cells express mature β cell genes, including MAFA and G6PC2, resembling native human islets.

Original languageEnglish
Article number108067
JournalCell Reports
Volume32
Issue number8
DOIs
StatePublished - Aug 25 2020

Keywords

  • IAPP
  • alpha cells
  • beta cells
  • diabetes
  • insulin
  • islets
  • sngle-cell RNA sequencing
  • stem cells
  • transcriptome

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