Single cell RNA-seq highlights a role for a partial EMT in head and neck cancer

Sidharth V. Puram; Anuraag S. Parikh; Itay Tirosh

doi:10.1080/23723556.2018.1448244

Single cell RNA-seq highlights a role for a partial EMT in head and neck cancer

Sidharth V. Puram
, Anuraag S. Parikh
, Itay Tirosh

Research output: Contribution to journal › Article › peer-review

64 Scopus citations

Abstract

Studies in single cell transcriptomics have significantly expanded our understanding of tumor biology, including recent analyses in head and neck squamous cell carcinoma. Here, we focus on the role of a partial epithelial-to-mesenchymal (EMT) program in these tumors, with discussion of its dynamics, regulation, and implications for diagnostic and therapeutic approaches.

Original language	English
Article number	e1448244
Journal	Molecular and Cellular Oncology
Volume	5
Issue number	3
DOIs	https://doi.org/10.1080/23723556.2018.1448244
State	Published - May 4 2018

Keywords

EMT
head and neck cancer
metastasis
single cell sequencing

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10.1080/23723556.2018.1448244

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title = "Single cell RNA-seq highlights a role for a partial EMT in head and neck cancer",

abstract = "Studies in single cell transcriptomics have significantly expanded our understanding of tumor biology, including recent analyses in head and neck squamous cell carcinoma. Here, we focus on the role of a partial epithelial-to-mesenchymal (EMT) program in these tumors, with discussion of its dynamics, regulation, and implications for diagnostic and therapeutic approaches.",

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AB - Studies in single cell transcriptomics have significantly expanded our understanding of tumor biology, including recent analyses in head and neck squamous cell carcinoma. Here, we focus on the role of a partial epithelial-to-mesenchymal (EMT) program in these tumors, with discussion of its dynamics, regulation, and implications for diagnostic and therapeutic approaches.

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KW - head and neck cancer

KW - metastasis

KW - single cell sequencing

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DO - 10.1080/23723556.2018.1448244

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Single cell RNA-seq highlights a role for a partial EMT in head and neck cancer

Abstract

Keywords

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