TY - JOUR
T1 - Single cell RNA-seq highlights a role for a partial EMT in head and neck cancer
AU - Puram, Sidharth V.
AU - Parikh, Anuraag S.
AU - Tirosh, Itay
N1 - Publisher Copyright:
© 2018, © 2018 Taylor & Francis Group, LLC.
PY - 2018/5/4
Y1 - 2018/5/4
N2 - Studies in single cell transcriptomics have significantly expanded our understanding of tumor biology, including recent analyses in head and neck squamous cell carcinoma. Here, we focus on the role of a partial epithelial-to-mesenchymal (EMT) program in these tumors, with discussion of its dynamics, regulation, and implications for diagnostic and therapeutic approaches.
AB - Studies in single cell transcriptomics have significantly expanded our understanding of tumor biology, including recent analyses in head and neck squamous cell carcinoma. Here, we focus on the role of a partial epithelial-to-mesenchymal (EMT) program in these tumors, with discussion of its dynamics, regulation, and implications for diagnostic and therapeutic approaches.
KW - EMT
KW - head and neck cancer
KW - metastasis
KW - single cell sequencing
UR - http://www.scopus.com/inward/record.url?scp=85050718809&partnerID=8YFLogxK
U2 - 10.1080/23723556.2018.1448244
DO - 10.1080/23723556.2018.1448244
M3 - Article
C2 - 30250901
AN - SCOPUS:85050718809
SN - 2372-3556
VL - 5
JO - Molecular and Cellular Oncology
JF - Molecular and Cellular Oncology
IS - 3
M1 - e1448244
ER -