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Single-Cell Analysis of Neonatal HSC Ontogeny Reveals Gradual and Uncoordinated Transcriptional Reprogramming that Begins before Birth
Yanan Li
, Wenjun Kong
, Wei Yang
, Riddhi M. Patel
, Emily B. Casey
, Theresa Okeyo-Owuor
, J. Michael White
, Shaina N. Porter
, Samantha A. Morris
,
Jeffrey A. Magee
Department of Developmental Biology
Center of Regenerative Medicine
Roy and Diana Vagelos Division of Biology & Biomedical Sciences (DBBS)
Department of Genetics
Siteman Cancer Center
Division of Hematology & Oncology
Bursky Center for Human Immunology & Immunotherapy Programs (CHiiPs)
Institute of Clinical and Translational Sciences (ICTS)
Hope Center for Neurological Disorders
DBBS - Computational and Systems Biology
DBBS - Biomedical Informatics and Data Science
DBBS - Developmental, Regenerative and Stem Cell Biology
DBBS - Molecular Genetics and Genomics
DBBS - Molecular Cell Biology
DBBS - Cancer Biology
Research output
:
Contribution to journal
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Article
›
peer-review
67
Scopus citations
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Dive into the research topics of 'Single-Cell Analysis of Neonatal HSC Ontogeny Reveals Gradual and Uncoordinated Transcriptional Reprogramming that Begins before Birth'. Together they form a unique fingerprint.
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Keyphrases
Hematopoietic Stem Cells
100%
Single-cell Analysis
100%
Transcriptional Reprogramming
100%
Gene Expression Profile
20%
Changes in Gene Expression
20%
Enhancer Element
20%
Proliferation Rate
20%
Cell Expansion
20%
Transcriptional States
20%
Type I Interferon Signaling
20%
Robust Networks
20%
Regulatory Programs
20%
Adult Hematopoietic Stem Cells
20%
Murine Hematopoietic Stem Cells
20%
Expression Gene
20%
Gene Enhancers
20%
FLT3-ITD
20%
Adult Identity
20%
Lineage Bias
20%
Enhancer Activation
20%
Gene Dependency
20%
Heterochronic
20%
Biochemistry, Genetics and Molecular Biology
Reprogramming
100%
Single-Cell Analysis
100%
Ontogeny
100%
Hematopoietic Cell
100%
Enhancer Region
28%
Gene Expression
28%
Spike
14%
Cell Expansion
14%
Interferon Type I
14%