Single agent bortezomib in the treatment of relapsed and refractory Hodgkin lymphoma: Cancer and leukemia Group B protocol 50206

Kristie A. Blum, Jeffrey L. Johnson, Donna Niedzwiecki, George P. Canellos, Bruce D. Cheson, Nancy L. Bartlett

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56 Scopus citations

Abstract

Constitutive activation of nuclear factor-κB (NF-κB) has been described in patient-derived Reed-Sternberg cells and Hodgkin lymphoma (HL) cell lines and contributes to the proliferation and survival of HL. Therapeutic inhibition of the proteasome with bortezomib may inhibit over-expression of nuclear NF-κB by preventing degradation of IκB, which sequesters NF-κB in the cytoplasm. To evaluate this hypothesis, the Cancer and Leukemia Group B (CALGB) conducted a multi-institutional phase II trial of single agent bortezomib in patients with relapsed or refractory classical HL. Thirty patients received bortezomib 1.3 mg/m2 on days 1, 4, 8, 11 and every 21 days for a median of 2 cycles (range, 1-8). Patients were heavily pre-treated with a median of four prior therapies, and 83% were previously transplanted. No responses were observed, 9 patients had stable disease, and 21 progressed. The median progression-free and overall survivals were 1.4 months [95% CI, (1.28, 1.91)] and 14.8 months [95% CI (11.2, 22.3)], respectively. Grade 3-4 adverse events, primarily thrombocytopenia, occurred in 15 patients. Therefore, although well tolerated, 1.3 mg/m2 bortezomib administered biweekly has no single agent activity in relapsed/refractory classical HL.

Original languageEnglish
Pages (from-to)1313-1319
Number of pages7
JournalLeukemia and Lymphoma
Volume48
Issue number7
DOIs
StatePublished - Jul 2007

Keywords

  • Bortezomib
  • Hodgkin lymphoma
  • Refractory
  • Relapsed

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