Simultaneous optimization of potency, selectivity and physicochemical properties for cannabinoid CB₂ ligands

Keyphrases

• Physicochemical Properties 100%
• Cannabinoids 100%
• Simultaneous Optimization 100%
• CB2 Ligands 100%
• CB2 Receptor 66%
• Novel Therapeutics 33%
• High Affinity 33%
• Non-selective 33%
• Analgesic 33%
• Rodent Models 33%
• Therapeutic Effect 33%
• Metabolic 33%
• Physiological Effects 33%
• Chronic Pain 33%
• Lead Optimization 33%
• In Vivo Efficacy 33%
• Oral Bioavailability 33%
• Metabolic Stability 33%
• Structural Modification 33%
• CB1 Receptor 33%
• Cannabinoid Receptor 2 33%
• CNS Side Effects 33%
• Lipophilic Ligands 33%
• CB2 Receptor Agonist 33%
• CB2 Agonist 33%
• Inflammation Pain 33%
• Ligand Display 33%
• Medicinal Chemistry Strategies 33%
• Cannabimimetics 33%
• Immunosuppressive Activity 33%
• Bioisosteric Replacement 33%
• Cannabinoid Ligands 33%
• Anticonvulsive 33%
• Hit Identification 33%
• Bioavailabilty 33%
• Liver Microsomal Stability 33%

Pharmacology, Toxicology and Pharmaceutical Science

• Cannabinoid 2 Receptor 100%
• Cannabinoid 2 Receptor Agonist 100%
• Cannabinoid 100%
• Inflammation 50%
• Structure Activity Relationship 50%
• Immunoglobulin 50%
• Side Effect 50%
• Analgesic Agent 50%
• Therapeutic Effect 50%
• Anti-Inflammatory Drug 50%
• Bioavailability 50%
• Chronic Pain 50%
• Pharmaceutical Chemistry 50%
• Cannabinoid 1 Receptor 50%