Simultaneous measurements of brain tissue pO2 and cerebral blood flow during functional stimulation

Beau M. Ances; Donald G. Buerk; Joel H. Greenberg; John A. Detre

doi:10.1016/S0531-5131(02)00182-6

Simultaneous measurements of brain tissue pO₂ and cerebral blood flow during functional stimulation

Beau M. Ances, Donald G. Buerk, Joel H. Greenberg, John A. Detre

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Simultaneous partial pressure of tissue oxygen (pO₂) and laser Doppler (LD) flowmetry measurements of cerebral blood flow (CBF) were obtained from the rat somatosensory cortex during periodic electrical forepaw stimulation of either 1-min or 4-s duration. For both stimulus durations, a transient significant decrease or “initial dip” in tissue pO₂ preceded blood flow changes, followed by a peak in blood flow and an overshoot in tissue pO₂. A sustained poststimulus undershoot in tissue pO₂ was observed only for the 1-min stimulus. The magnitude of this poststimulus tissue pO₂ decrease was significantly greater than the “initial dip” observed after stimulus onset, suggesting that relative tissue hypoxia alone does not mediate blood flow changes observed with functional stimulation. Our results suggest a complex dynamic relationship between oxygen utilization and blood flow exists during functional stimulation.

Original language	English
Pages (from-to)	155-163
Number of pages	9
Journal	International Congress Series
Volume	1235
Issue number	C
DOIs	https://doi.org/10.1016/S0531-5131(02)00182-6
State	Published - Jul 1 2002

Keywords

Cerebral blood flow
Laser Doppler flowmetry
Tissue oxygen electrode

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10.1016/S0531-5131(02)00182-6

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title = "Simultaneous measurements of brain tissue pO2 and cerebral blood flow during functional stimulation",

abstract = "Simultaneous partial pressure of tissue oxygen (pO2) and laser Doppler (LD) flowmetry measurements of cerebral blood flow (CBF) were obtained from the rat somatosensory cortex during periodic electrical forepaw stimulation of either 1-min or 4-s duration. For both stimulus durations, a transient significant decrease or “initial dip” in tissue pO2 preceded blood flow changes, followed by a peak in blood flow and an overshoot in tissue pO2. A sustained poststimulus undershoot in tissue pO2 was observed only for the 1-min stimulus. The magnitude of this poststimulus tissue pO2 decrease was significantly greater than the “initial dip” observed after stimulus onset, suggesting that relative tissue hypoxia alone does not mediate blood flow changes observed with functional stimulation. Our results suggest a complex dynamic relationship between oxygen utilization and blood flow exists during functional stimulation.",

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AU - Ances, Beau M.

AU - Buerk, Donald G.

AU - Greenberg, Joel H.

AU - Detre, John A.

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AB - Simultaneous partial pressure of tissue oxygen (pO2) and laser Doppler (LD) flowmetry measurements of cerebral blood flow (CBF) were obtained from the rat somatosensory cortex during periodic electrical forepaw stimulation of either 1-min or 4-s duration. For both stimulus durations, a transient significant decrease or “initial dip” in tissue pO2 preceded blood flow changes, followed by a peak in blood flow and an overshoot in tissue pO2. A sustained poststimulus undershoot in tissue pO2 was observed only for the 1-min stimulus. The magnitude of this poststimulus tissue pO2 decrease was significantly greater than the “initial dip” observed after stimulus onset, suggesting that relative tissue hypoxia alone does not mediate blood flow changes observed with functional stimulation. Our results suggest a complex dynamic relationship between oxygen utilization and blood flow exists during functional stimulation.

KW - Cerebral blood flow

KW - Laser Doppler flowmetry

KW - Tissue oxygen electrode

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Simultaneous measurements of brain tissue pO₂ and cerebral blood flow during functional stimulation

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