Simultaneous measurements of brain tissue pO2 and cerebral blood flow during functional stimulation

Beau M. Ances, Donald G. Buerk, Joel H. Greenberg, John A. Detre

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Simultaneous partial pressure of tissue oxygen (pO2) and laser Doppler (LD) flowmetry measurements of cerebral blood flow (CBF) were obtained from the rat somatosensory cortex during periodic electrical forepaw stimulation of either 1-min or 4-s duration. For both stimulus durations, a transient significant decrease or “initial dip” in tissue pO2 preceded blood flow changes, followed by a peak in blood flow and an overshoot in tissue pO2. A sustained poststimulus undershoot in tissue pO2 was observed only for the 1-min stimulus. The magnitude of this poststimulus tissue pO2 decrease was significantly greater than the “initial dip” observed after stimulus onset, suggesting that relative tissue hypoxia alone does not mediate blood flow changes observed with functional stimulation. Our results suggest a complex dynamic relationship between oxygen utilization and blood flow exists during functional stimulation.

Original languageEnglish
Pages (from-to)155-163
Number of pages9
JournalInternational Congress Series
Volume1235
Issue numberC
DOIs
StatePublished - Jul 1 2002

Keywords

  • Cerebral blood flow
  • Laser Doppler flowmetry
  • Tissue oxygen electrode

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