Simultaneous imaging of amyloid deposition and cerebrovascular function using dual-contrast photoacoustic microscopy

Yifeng Zhou, Fenghe Zhong, Ping Yan, Jin Moo Lee, Song Hu

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Pathological aggregation of Aβ peptides results in the deposition of amyloid in the brain parenchyma (senile plaques in Alzheimer’s disease [AD]) and around cerebral microvessels (cerebral amyloid angiopathy [CAA]). Our current understanding of the amyloid-induced microvascular changes has been limited to the structure and hemodynamics—leaving the oxygen-metabolic aspect unattended. In this Letter, we report a dual-contrast photoacoustic microscopy (PAM) technique, which integrates the molecular contrast of dichroism PAM and the physiological contrast of multi-parametric PAM for simultaneous, intravital imaging of amyloid deposition and cerebrovascular function in a mouse model that develops AD and CAA. This technique opens up new opportunities to study the spatiotemporal interplay between amyloid deposition and vascular-metabolic dysfunction in AD and CAA.

Original languageEnglish
Pages (from-to)2561-2564
Number of pages4
JournalOptics Letters
Volume46
Issue number11
DOIs
StatePublished - Jun 1 2021

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