Simultaneous cotargeting of ATR and RNA polymerase I transcription demonstrates synergistic antileukemic effects on acute myeloid leukemia

Tingting Wang; Margaret Shatara; Fangbing Liu; Tristan Knight; Holly Edwards; Guan Wang; Hai Lin; Yue Wang; Jeffrey W. Taub; Yubin Ge

doi:10.1038/s41392-019-0076-3

Simultaneous cotargeting of ATR and RNA polymerase I transcription demonstrates synergistic antileukemic effects on acute myeloid leukemia

Tingting Wang, Margaret Shatara, Fangbing Liu, Tristan Knight, Holly Edwards, Guan Wang, Hai Lin, Yue Wang, Jeffrey W. Taub, Yubin Ge

Research output: Contribution to journal › Letter › peer-review

3 Scopus citations

Original language	English
Article number	44
Journal	Signal Transduction and Targeted Therapy
Volume	4
Issue number	1
DOIs	https://doi.org/10.1038/s41392-019-0076-3
State	Published - 2019

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10.1038/s41392-019-0076-3

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@article{c2487ed7a050477e8adc9a1fb716c528,

title = "Simultaneous cotargeting of ATR and RNA polymerase I transcription demonstrates synergistic antileukemic effects on acute myeloid leukemia",

author = "Tingting Wang and Margaret Shatara and Fangbing Liu and Tristan Knight and Holly Edwards and Guan Wang and Hai Lin and Yue Wang and Taub, {Jeffrey W.} and Yubin Ge",

note = "Funding Information: This study was supported by Jilin University, Changchun, China; the Barbara Ann Karmanos Cancer Institute; Wayne State University School of Medicine, and grants from the National Natural Science Foundation of China (NSFC 31671438 and NSFC 31471295), National Key Research and Development Program of China (2017YFC1702103), Hyundai Hope on Wheels, LaFontaine Family/U Can-Cer Vive Foundation, Kids Without Cancer, Children{\textquoteright}s Hospital of Michigan Foundation, Decerchio/Guisewite Family, Justin{\textquoteright}s Gift, Elana Fund, Ginopolis/Karmanos Endowment and the Ring Screw Textron Endowed Chair for Pediatric Cancer Research, and the Ingrid and Ashok Sarnaik Endowment Grant. The funders had no role in study design, data collection, data analysis and interpretation, decision to publish, or paper preparation. Funding Information: This study was supported by Jilin University, Changchun, China; the Barbara Ann Karmanos Cancer Institute; Wayne State University School of Medicine, and grants from the National Natural Science Foundation of China (NSFC 31671438 and NSFC 31471295), National Key Research and Development Program of China (2017YFC1702103), Hyundai Hope on Wheels, LaFontaine Family/U Cancer Vive Foundation, Kids Without Cancer, Children{\textquoteright}s Hospital of Michigan Foundation, Decerchio/Guisewite Family, Justin{\textquoteright}s Gift, Elana Fund, Ginopolis/Karmanos Endowment and the Ring Screw Textron Endowed Chair for Pediatric Cancer Research, and the Ingrid and Ashok Sarnaik Endowment Grant. The funders had no role in study design, data collection, data analysis and interpretation, decision to publish, or paper preparation.",

year = "2019",

doi = "10.1038/s41392-019-0076-3",

language = "English",

volume = "4",

journal = "Signal Transduction and Targeted Therapy",

issn = "2095-9907",

number = "1",

}

TY - JOUR

T1 - Simultaneous cotargeting of ATR and RNA polymerase I transcription demonstrates synergistic antileukemic effects on acute myeloid leukemia

AU - Wang, Tingting

AU - Shatara, Margaret

AU - Liu, Fangbing

AU - Knight, Tristan

AU - Edwards, Holly

AU - Wang, Guan

AU - Lin, Hai

AU - Wang, Yue

AU - Taub, Jeffrey W.

AU - Ge, Yubin

N1 - Funding Information: This study was supported by Jilin University, Changchun, China; the Barbara Ann Karmanos Cancer Institute; Wayne State University School of Medicine, and grants from the National Natural Science Foundation of China (NSFC 31671438 and NSFC 31471295), National Key Research and Development Program of China (2017YFC1702103), Hyundai Hope on Wheels, LaFontaine Family/U Can-Cer Vive Foundation, Kids Without Cancer, Children’s Hospital of Michigan Foundation, Decerchio/Guisewite Family, Justin’s Gift, Elana Fund, Ginopolis/Karmanos Endowment and the Ring Screw Textron Endowed Chair for Pediatric Cancer Research, and the Ingrid and Ashok Sarnaik Endowment Grant. The funders had no role in study design, data collection, data analysis and interpretation, decision to publish, or paper preparation. Funding Information: This study was supported by Jilin University, Changchun, China; the Barbara Ann Karmanos Cancer Institute; Wayne State University School of Medicine, and grants from the National Natural Science Foundation of China (NSFC 31671438 and NSFC 31471295), National Key Research and Development Program of China (2017YFC1702103), Hyundai Hope on Wheels, LaFontaine Family/U Cancer Vive Foundation, Kids Without Cancer, Children’s Hospital of Michigan Foundation, Decerchio/Guisewite Family, Justin’s Gift, Elana Fund, Ginopolis/Karmanos Endowment and the Ring Screw Textron Endowed Chair for Pediatric Cancer Research, and the Ingrid and Ashok Sarnaik Endowment Grant. The funders had no role in study design, data collection, data analysis and interpretation, decision to publish, or paper preparation.

PY - 2019

Y1 - 2019

UR - http://www.scopus.com/inward/record.url?scp=85081724360&partnerID=8YFLogxK

U2 - 10.1038/s41392-019-0076-3

DO - 10.1038/s41392-019-0076-3

M3 - Letter

C2 - 31700693

AN - SCOPUS:85081724360

SN - 2095-9907

VL - 4

JO - Signal Transduction and Targeted Therapy

JF - Signal Transduction and Targeted Therapy

IS - 1

M1 - 44

ER -

Simultaneous cotargeting of ATR and RNA polymerase I transcription demonstrates synergistic antileukemic effects on acute myeloid leukemia

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