Simulation of spontaneous G protein activation reveals a new intermediate driving GDP unbinding

Keyphrases

• Binding Site 100%
• Helix 100%
• G Protein 100%
• G-protein Activation 100%
• Allosteric Network 100%
• GDP Release 100%
• Markov State Model 50%
• Signaling Cascades 50%
• Biochemical Data 50%
• Structural Information 50%
• Conformational Change 50%
• Slow Events 50%
• Protein mutants 50%
• Rate-limiting Step 50%
• Computational Methods 50%
• Detailed Model 50%
• Nucleotide Binding Site 50%
• Metadynamics 50%
• Off-rate 50%
• Correlated Motion 50%
• Allosteric Communication 50%

Biochemistry, Genetics and Molecular Biology

• G Protein 100%
• Binding Site 66%
• G Protein Coupled Receptor 66%
• Mutant Protein 33%
• Motion 33%
• Conformational Change 33%
• Heterotrimeric G Protein 33%
• Nucleotide Binding Site 33%
• Metadynamic 33%