TY - JOUR
T1 - Simulation of harmonic shear waves in the human brain and comparison with measurements from magnetic resonance elastography
AU - Li, Yang
AU - Okamoto, Ruth
AU - Badachhape, Andrew
AU - Wu, Chengwei
AU - Bayly, Philip
AU - Daphalapurkar, Nitin
N1 - Funding Information:
Authors ND and YL are grateful to Drs. K.T. Ramesh, Y.-C. Lu, and S.G. Ganpule for fruitful discussions. Authors acknowledge funding from the National Institute of Neurological Disorders and Strokes, US National Institutes of Health (Project #R01NS055951).
Publisher Copyright:
© 2021
PY - 2021/6
Y1 - 2021/6
N2 - Magnetic Resonance Elastography (MRE) provides a non-invasive method to characterize the mechanical response of the living brain subjected to harmonic loading conditions. The peak magnitude of the harmonic strain is small and the excitation results in harmless deformation waves propagating through the brain. In this paper, we describe a three-dimensional computational model of the brain for comparison of simulated harmonic deformations of the brain with MRE measurements. Relevant substructures of the head were constructed from MRI scans. Harmonic wave motions in a live human brain obtained in an MRE experiment were used to calibrate the viscoelastic properties at 50 Hz and assess accuracy of the computational model by comparing the measured and the simulated harmonic response of the brain. Quantitative comparison of strain field from simulations with measured data from MRE shows that the harmonic deformation of the brain tissue is responsive to changes in the viscoelastic properties, loss and storage moduli, of the brain. The simulation results demonstrate, in agreement with MRE measurements, that the presence of the falx and tentorium membranes alter the spatial distribution of harmonic deformation field and peak strain amplitudes in the computational model of the brain.
AB - Magnetic Resonance Elastography (MRE) provides a non-invasive method to characterize the mechanical response of the living brain subjected to harmonic loading conditions. The peak magnitude of the harmonic strain is small and the excitation results in harmless deformation waves propagating through the brain. In this paper, we describe a three-dimensional computational model of the brain for comparison of simulated harmonic deformations of the brain with MRE measurements. Relevant substructures of the head were constructed from MRI scans. Harmonic wave motions in a live human brain obtained in an MRE experiment were used to calibrate the viscoelastic properties at 50 Hz and assess accuracy of the computational model by comparing the measured and the simulated harmonic response of the brain. Quantitative comparison of strain field from simulations with measured data from MRE shows that the harmonic deformation of the brain tissue is responsive to changes in the viscoelastic properties, loss and storage moduli, of the brain. The simulation results demonstrate, in agreement with MRE measurements, that the presence of the falx and tentorium membranes alter the spatial distribution of harmonic deformation field and peak strain amplitudes in the computational model of the brain.
KW - Brain biomechanics
KW - Finite element method
KW - Shear waves
KW - Viscoelasticity
UR - http://www.scopus.com/inward/record.url?scp=85102850173&partnerID=8YFLogxK
U2 - 10.1016/j.jmbbm.2021.104449
DO - 10.1016/j.jmbbm.2021.104449
M3 - Article
C2 - 33770585
AN - SCOPUS:85102850173
SN - 1751-6161
VL - 118
JO - Journal of the Mechanical Behavior of Biomedical Materials
JF - Journal of the Mechanical Behavior of Biomedical Materials
M1 - 104449
ER -