A simple, inexpensive dual-detector system has been developed for measurement of positron-emitting receptor-binding drugs in the human brain. This high efficiency coincidence counting system requires that only a few hundred microcuries of labeled drug be administered to the subject, thereby allowing for multiple studies without an excessive radiation dose. Measurement of the binding of [11C]carfentanil, a high affinity synthetic opiate, to opiate receptors in the presence and in the absence of a competitive opiate antagonist indicates that potential utility of this system for estimating different degrees of receptor occupation in the human brain.
|Number of pages||8|
|Journal||Journal of Nuclear Medicine|
|State||Published - 1986|