Abstract
A simple, inexpensive dual-detector system has been developed for measurement of positron-emitting receptor-binding drugs in the human brain. This high efficiency coincidence counting system requires that only a few hundred microcuries of labeled drug be administered to the subject, thereby allowing for multiple studies without an excessive radiation dose. Measurement of the binding of [11C]carfentanil, a high affinity synthetic opiate, to opiate receptors in the presence and in the absence of a competitive opiate antagonist indicates that potential utility of this system for estimating different degrees of receptor occupation in the human brain.
Original language | English |
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Pages (from-to) | 184-191 |
Number of pages | 8 |
Journal | Journal of Nuclear Medicine |
Volume | 27 |
Issue number | 2 |
State | Published - 1986 |