TY - JOUR
T1 - Similar effects of high-fructose and high-glucose feeding in a Drosophila model of obesity and diabetes
AU - Musselman, Laura Palanker
AU - Fink, Jill L.
AU - Baranski, Thomas J.
N1 - Funding Information:
This study was funded by the Diabetes Action Research and Education Foundation (https://diabetesaction.org/) to LPM and the Diabetes Research Training Center at Washington University (https://diabetesresearchcenter.dom. wustl.edu/) via NIH grant P60DK020579-34 to LPM. The Washington University Genome Technology Access Center is partially supported by NCI Cancer Center Support Grant #P30 CA91842 to the Siteman Cancer Center and by ICTS/CTSA Grant# UL1 TR000448. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. We thank Eric Tycksen and the Genome Technology Access Center in the Department of Genetics at Washington University School of Medicine for help with genomic analysis. We also thank the Vienna Drosophila Resource Center and the Developmental Studies Hybridoma Bank for generating reagents to support this work.
Publisher Copyright:
© 2019 Musselman et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
PY - 2019/5
Y1 - 2019/5
N2 - As in mammals, high-sucrose diets lead to obesity and insulin resistance in the model organism Drosophila melanogaster (called Drosophila hereafter). To explore the relative contributions of glucose and fructose, sucrose’s component monosaccharides, we compared their effects on larval physiology. Both sugars exhibited similar effects to sucrose, leading to obesity and hyperglycemia. There were no striking differences resulting from larvae fed high glucose versus high fructose. Some small but statistically significant differences in weight and gene expression were observed that suggest Drosophila is a promising model system for understanding monosaccharide-specific effects on metabolic homeostasis.
AB - As in mammals, high-sucrose diets lead to obesity and insulin resistance in the model organism Drosophila melanogaster (called Drosophila hereafter). To explore the relative contributions of glucose and fructose, sucrose’s component monosaccharides, we compared their effects on larval physiology. Both sugars exhibited similar effects to sucrose, leading to obesity and hyperglycemia. There were no striking differences resulting from larvae fed high glucose versus high fructose. Some small but statistically significant differences in weight and gene expression were observed that suggest Drosophila is a promising model system for understanding monosaccharide-specific effects on metabolic homeostasis.
UR - http://www.scopus.com/inward/record.url?scp=85065905444&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0217096
DO - 10.1371/journal.pone.0217096
M3 - Article
C2 - 31091299
AN - SCOPUS:85065905444
SN - 1932-6203
VL - 14
JO - PLoS ONE
JF - PLoS ONE
IS - 5
M1 - e0217096
ER -