Silyl-Substituted Amino Acids: New Routes to the Construction of Selectively Functionalized Peptidomimetics

Haizhou Sun; Kevin D. Moeller

doi:10.1021/ol025776e

Silyl-Substituted Amino Acids: New Routes to the Construction of Selectively Functionalized Peptidomimetics

Haizhou Sun, Kevin D. Moeller

Research output: Contribution to journal › Article › peer-review

72 Scopus citations

Abstract

(matrix presented) Silylated amino acids have been incorporated into peptides and then converted into N-acyliminium ions with the use of an anodic oxidation reaction. The result is a method for selectively incorporating conformational constraints or external nucleophiles within the peptide.

Original language	English
Pages (from-to)	1547-1550
Number of pages	4
Journal	Organic Letters
Volume	4
Issue number	9
DOIs	https://doi.org/10.1021/ol025776e
State	Published - May 2 2002

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abstract = "(matrix presented) Silylated amino acids have been incorporated into peptides and then converted into N-acyliminium ions with the use of an anodic oxidation reaction. The result is a method for selectively incorporating conformational constraints or external nucleophiles within the peptide.",

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AB - (matrix presented) Silylated amino acids have been incorporated into peptides and then converted into N-acyliminium ions with the use of an anodic oxidation reaction. The result is a method for selectively incorporating conformational constraints or external nucleophiles within the peptide.

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Silyl-Substituted Amino Acids: New Routes to the Construction of Selectively Functionalized Peptidomimetics

Abstract

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