Silybum marianum (milk thistle) in the management and prevention of hepatotoxicity in a patient undergoing reinduction therapy for acute myelogenous leukemia

Ali McBride, Kristan M. Augustin, Julie Nobbe, Peter Westervelt

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Hepatotoxicity has been observed with several chemotherapy agents and combination regimens. Conventional treatment methods often include supportive care or observation. We report a case of a patient with noted transaminitis presumed secondary to chemotherapy, which did not resolve with supportive care but was shown to respond to milk thistle. The patient had an immediate decrease in liver function tests and showed decreased elevation in levels upon treatment with subsequent chemotherapy regimens. This case demonstrates the potential efficacy of milk thistle as a unique hepatoprotective agent.

Original languageEnglish
Pages (from-to)360-365
Number of pages6
JournalJournal of Oncology Pharmacy Practice
Volume18
Issue number3
DOIs
StatePublished - Sep 1 2012

Keywords

  • Milk thistle
  • chemotherapy
  • silybin
  • silymarin
  • transaminitis

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