Silicon photonic microring resonator arrays for scalable and multiplexable bioanalysis

Matthew S. Luchansky, Adam L. Washburn, Abraham J. Qavi, Jared T. Kindt, Melinda S. McClellan, Ryan C. Bailey

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

2 Scopus citations

Abstract

Silicon photonic devices, such as SOI microring resonators, have optical properties that are incredibly responsive to changes in the local dielectric environment accompanying a biological binding event at or near the ring surface. We have developed a platform in which arrays of uniquely addressable microrings are functionalized with target-specific capture agents so as to create a powerful tool for multiplexed biomolecular detection. We will discuss applications of this technology to the multiplexed detection of DNA, RNA, and proteins in clinically-relevant matrices, and will also describe the rigorous empirical determination of key sensitivity metrics.

Original languageEnglish
Title of host publicationFrontiers in Biological Detection
Subtitle of host publicationFrom Nanosensors to Systems III
DOIs
StatePublished - 2011
EventFrontiers in Biological Detection: From Nanosensors to Systems III - San Francisco, CA, United States
Duration: Jan 22 2011Jan 23 2011

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume7888
ISSN (Print)1605-7422

Conference

ConferenceFrontiers in Biological Detection: From Nanosensors to Systems III
Country/TerritoryUnited States
CitySan Francisco, CA
Period01/22/1101/23/11

Keywords

  • Biosensors
  • label-free
  • microring resonators
  • silicon photonics
  • silicon-on-insulator

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