Sildenafil in Left Ventricular Assist Device Is Safe and Well-Tolerated

Ashwin K. Ravichandran; Shane J. LaRue; Eric Novak; Susan A. Joseph; Joel D. Schilling

doi:10.1097/MAT.0000000000000626

Sildenafil in Left Ventricular Assist Device Is Safe and Well-Tolerated

Ashwin K. Ravichandran, Shane J. LaRue, Eric Novak, Susan A. Joseph, Joel D. Schilling

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

Right heart failure is a potentially devastating complication of mechanical circulatory support, occurring at a rate of 0.49 events per 100 patient-months.¹ Pulmonary vasodilators such as phosphodiesterase-5 inhibitors (PDE5i) have been frequently used to unload the right ventricle in left ventricular assist device (LVAD) patients, but there is scant evidence to support this practice.^2,3 The purpose of this analysis is to provide additional data regarding the safety and efficacy of the PDE5i sildenafil in a real world population of patients supported with LVADs at Washington University in St. Louis. Sildenafil use was not associated with differences in gastrointestinal (GI) bleeding, stroke, mortality, heart failure (HF) admission, or orthotopic heart transplantation (OHT).

Original language	English
Pages (from-to)	280-281
Number of pages	2
Journal	ASAIO Journal
Volume	64
Issue number	2
DOIs	https://doi.org/10.1097/MAT.0000000000000626
State	Published - Mar 1 2018

Keywords

left ventricular assist device
pulmonary hypertension
right heart failure
safety
sildenafil

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10.1097/MAT.0000000000000626

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title = "Sildenafil in Left Ventricular Assist Device Is Safe and Well-Tolerated",

abstract = "Right heart failure is a potentially devastating complication of mechanical circulatory support, occurring at a rate of 0.49 events per 100 patient-months.1 Pulmonary vasodilators such as phosphodiesterase-5 inhibitors (PDE5i) have been frequently used to unload the right ventricle in left ventricular assist device (LVAD) patients, but there is scant evidence to support this practice.2,3 The purpose of this analysis is to provide additional data regarding the safety and efficacy of the PDE5i sildenafil in a real world population of patients supported with LVADs at Washington University in St. Louis. Sildenafil use was not associated with differences in gastrointestinal (GI) bleeding, stroke, mortality, heart failure (HF) admission, or orthotopic heart transplantation (OHT).",

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author = "Ravichandran, {Ashwin K.} and LaRue, {Shane J.} and Eric Novak and Joseph, {Susan A.} and Schilling, {Joel D.}",

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AU - Ravichandran, Ashwin K.

AU - LaRue, Shane J.

AU - Novak, Eric

AU - Joseph, Susan A.

AU - Schilling, Joel D.

PY - 2018/3/1

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AB - Right heart failure is a potentially devastating complication of mechanical circulatory support, occurring at a rate of 0.49 events per 100 patient-months.1 Pulmonary vasodilators such as phosphodiesterase-5 inhibitors (PDE5i) have been frequently used to unload the right ventricle in left ventricular assist device (LVAD) patients, but there is scant evidence to support this practice.2,3 The purpose of this analysis is to provide additional data regarding the safety and efficacy of the PDE5i sildenafil in a real world population of patients supported with LVADs at Washington University in St. Louis. Sildenafil use was not associated with differences in gastrointestinal (GI) bleeding, stroke, mortality, heart failure (HF) admission, or orthotopic heart transplantation (OHT).

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Sildenafil in Left Ventricular Assist Device Is Safe and Well-Tolerated

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