TY - JOUR
T1 - Significant left ventricular contribution to right ventricular systolic function
AU - Damiano, R. J.
AU - La Follette, P.
AU - Cox, J. L.
AU - Lowe, J. E.
AU - Santamore, W. P.
PY - 1991
Y1 - 1991
N2 - To examine the importance of systolic ventricular interdependence on right ventricular function, we used a unique electrically isolated right ventricular free wall preparation. Double-peaked waveforms for right ventricular pressure and pulmonary arterial blood flow occurred over a wide range of pacing intervals between the left and right ventricles. One component of the waveforms could be directly related to right ventricular free wall contraction, whereas the other component was directly related to left ventricular and septal contraction. For left ventricular pressure, the left ventricular component was significantly larger than the right ventricular free wall component (92.7 ± 3.2 vs. 7.3 ± 3.2% peak-to-peak value, P < 0.01). For right ventricular pressure, the left ventricular and septal component was significantly greater than the right ventricular component (63.5 ± 10.9 vs. 36.5 ± 10.9% peak-to-peak value, P < 0.05). Similarly, for pulmonary arterial blood flow, the left ventricular component was significantly greater than the right ventricular component. When right ventricular free wall pacing stopped in diastole, 68 ± 4% of right ventricular systolic pressure and 80 ± 4% of pulmonary flow were obtained in the subsequent beat. The results of this study indicate that left ventricular contraction is very important for right ventricular developed pressure and volume outflow.
AB - To examine the importance of systolic ventricular interdependence on right ventricular function, we used a unique electrically isolated right ventricular free wall preparation. Double-peaked waveforms for right ventricular pressure and pulmonary arterial blood flow occurred over a wide range of pacing intervals between the left and right ventricles. One component of the waveforms could be directly related to right ventricular free wall contraction, whereas the other component was directly related to left ventricular and septal contraction. For left ventricular pressure, the left ventricular component was significantly larger than the right ventricular free wall component (92.7 ± 3.2 vs. 7.3 ± 3.2% peak-to-peak value, P < 0.01). For right ventricular pressure, the left ventricular and septal component was significantly greater than the right ventricular component (63.5 ± 10.9 vs. 36.5 ± 10.9% peak-to-peak value, P < 0.05). Similarly, for pulmonary arterial blood flow, the left ventricular component was significantly greater than the right ventricular component. When right ventricular free wall pacing stopped in diastole, 68 ± 4% of right ventricular systolic pressure and 80 ± 4% of pulmonary flow were obtained in the subsequent beat. The results of this study indicate that left ventricular contraction is very important for right ventricular developed pressure and volume outflow.
KW - Cardiac mechanics
KW - Left ventricle
KW - Right ventricle
KW - Ventricular interdependence
UR - http://www.scopus.com/inward/record.url?scp=0026338407&partnerID=8YFLogxK
U2 - 10.1152/ajpheart.1991.261.5.h1514
DO - 10.1152/ajpheart.1991.261.5.h1514
M3 - Article
C2 - 1951739
AN - SCOPUS:0026338407
VL - 261
SP - H1514-H1524
JO - American Journal of Physiology - Heart and Circulatory Physiology
JF - American Journal of Physiology - Heart and Circulatory Physiology
SN - 0363-6135
IS - 5 30-5
ER -