Die Bedeutung von ICAM-1 auf die Lyse von humanen Pankreaskarzinomzellen durch autologe, zytotoxische T-Lymphozyten.

Translated title of the contribution: Significance if ICAM-1 on lysis of human pancreatic carcinoma cells by autologous, cytotoxic T-lymphocytes

M. Peiper, Simon Goedegebuure, Timothy Eberlein, C. E. Broelsch

Research output: Contribution to journalArticlepeer-review

Abstract

Cytotoxic T-Lymphocytes were generated from tumor-infiltrating lymphocytes of a newly established pancreatic cancer cell line, which lysed autologous tumor cells significantly and HLA-class I restricted. ICAM-1+ tumor clones were significantly higher lysed than an ICAM-1- clone. Stimulation with IFN-gamma resulted in a higher expression of ICAM-1 and significantly higher lysis, which was inhibited by anti-ICAM-1 monoclonal antibodies.

Translated title of the contributionSignificance if ICAM-1 on lysis of human pancreatic carcinoma cells by autologous, cytotoxic T-lymphocytes
Original languageGerman
Pages (from-to)59-62
Number of pages4
JournalLangenbecks Archiv für Chirurgie. Supplement. Kongressband. Deutsche Gesellschaft für Chirurgie. Kongress
Volume115
Issue numberSuppl I
StatePublished - 1998

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