Signatures of adaptation to obligate biotrophy in the Hyaloperonospora arabidopsidis genome

Laura Baxter; Sucheta Tripathy; Naveed Ishaque; Nico Boot; Adriana Cabral; Eric Kemen; Marco Thines; Audrey Ah-Fong; Ryan Anderson; Wole Badejoko; Peter Bittner-Eddy; Jeffrey L. Boore; Marcus C. Chibucos; Mary Coates; Paramvir Dehal; Kim Delehaunty; Suomeng Dong; Polly Downton; Bernard Dumas; Georgina Fabro; Catrina Fronick; Susan I. Fuerstenberg; Lucinda Fulton; Elodie Gaulin; Francine Govers; Linda Hughes; Sean Humphray; Rays H.Y. Jiang; Howard Judelson; Sophien Kamoun; Kim Kyung; Harold Meijer; Patrick Minx; Paul Morris; Joanne Nelson; Vipa Phuntumart; Dinah Qutob; Anne Rehmany; Alejandra Rougon-Cardoso; Peter Ryden; Trudy Torto-Alalibo; David Studholme; Yuanchao Wang; Joe Win; Jo Wood; Sandra W. Clifton; Jane Rogers; Guido Van Den Ackerveken; Jonathan D.G. Jones; John M. McDowell; Jim Beynon; Brett M. Tyler

doi:10.1126/science.1195203

Signatures of adaptation to obligate biotrophy in the Hyaloperonospora arabidopsidis genome

Laura Baxter, Sucheta Tripathy, Naveed Ishaque, Nico Boot, Adriana Cabral, Eric Kemen, Marco Thines, Audrey Ah-Fong, Ryan Anderson, Wole Badejoko, Peter Bittner-Eddy, Jeffrey L. Boore, Marcus C. Chibucos, Mary Coates, Paramvir Dehal, Kim Delehaunty, Suomeng Dong, Polly Downton, Bernard Dumas, Georgina FabroCatrina Fronick, Susan I. Fuerstenberg, Lucinda Fulton, Elodie Gaulin, Francine Govers, Linda Hughes, Sean Humphray, Rays H.Y. Jiang, Howard Judelson, Sophien Kamoun, Kim Kyung, Harold Meijer, Patrick Minx, Paul Morris, Joanne Nelson, Vipa Phuntumart, Dinah Qutob, Anne Rehmany, Alejandra Rougon-Cardoso, Peter Ryden, Trudy Torto-Alalibo, David Studholme, Yuanchao Wang, Joe Win, Jo Wood, Sandra W. Clifton, Jane Rogers, Guido Van Den Ackerveken, Jonathan D.G. Jones, John M. McDowell, Jim Beynon, Brett M. Tyler

McDonnell Genome Institute (MGI)

Research output: Contribution to journal › Article › peer-review

372 Scopus citations

Abstract

Many oomycete and fungal plant pathogens are obligate biotrophs, which extract nutrients only from living plant tissue and cannot grow apart from their hosts. Although these pathogens cause substantial crop losses, little is known about the molecular basis or evolution of obligate biotrophy. Here, we report the genome sequence of the oomycete Hyaloperonospora arabidopsidis (Hpa), an obligate biotroph and natural pathogen of Arabidopsis thaliana. In comparison with genomes of related, hemibiotrophic Phytophthora species, the Hpa genome exhibits dramatic reductions in genes encoding (i) RXLR effectors and other secreted pathogenicity proteins, (ii) enzymes for assimilation of inorganic nitrogen and sulfur, and (iii) proteins associated with zoospore formation and motility. These attributes comprise a genomic signature of evolution toward obligate biotrophy.

Original language	English
Pages (from-to)	1549-1551
Number of pages	3
Journal	Science
Volume	330
Issue number	6010
DOIs	https://doi.org/10.1126/science.1195203
State	Published - Dec 10 2010

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Baxter, L., Tripathy, S., Ishaque, N., Boot, N., Cabral, A., Kemen, E., Thines, M., Ah-Fong, A., Anderson, R., Badejoko, W., Bittner-Eddy, P., Boore, J. L., Chibucos, M. C., Coates, M., Dehal, P., Delehaunty, K., Dong, S., Downton, P., Dumas, B., ... Tyler, B. M. (2010). Signatures of adaptation to obligate biotrophy in the Hyaloperonospora arabidopsidis genome. Science, 330(6010), 1549-1551. https://doi.org/10.1126/science.1195203

@article{187b071f37924ef98a42ac31f6f1ddbb,

title = "Signatures of adaptation to obligate biotrophy in the Hyaloperonospora arabidopsidis genome",

abstract = "Many oomycete and fungal plant pathogens are obligate biotrophs, which extract nutrients only from living plant tissue and cannot grow apart from their hosts. Although these pathogens cause substantial crop losses, little is known about the molecular basis or evolution of obligate biotrophy. Here, we report the genome sequence of the oomycete Hyaloperonospora arabidopsidis (Hpa), an obligate biotroph and natural pathogen of Arabidopsis thaliana. In comparison with genomes of related, hemibiotrophic Phytophthora species, the Hpa genome exhibits dramatic reductions in genes encoding (i) RXLR effectors and other secreted pathogenicity proteins, (ii) enzymes for assimilation of inorganic nitrogen and sulfur, and (iii) proteins associated with zoospore formation and motility. These attributes comprise a genomic signature of evolution toward obligate biotrophy.",

author = "Laura Baxter and Sucheta Tripathy and Naveed Ishaque and Nico Boot and Adriana Cabral and Eric Kemen and Marco Thines and Audrey Ah-Fong and Ryan Anderson and Wole Badejoko and Peter Bittner-Eddy and Boore, {Jeffrey L.} and Chibucos, {Marcus C.} and Mary Coates and Paramvir Dehal and Kim Delehaunty and Suomeng Dong and Polly Downton and Bernard Dumas and Georgina Fabro and Catrina Fronick and Fuerstenberg, {Susan I.} and Lucinda Fulton and Elodie Gaulin and Francine Govers and Linda Hughes and Sean Humphray and Jiang, {Rays H.Y.} and Howard Judelson and Sophien Kamoun and Kim Kyung and Harold Meijer and Patrick Minx and Paul Morris and Joanne Nelson and Vipa Phuntumart and Dinah Qutob and Anne Rehmany and Alejandra Rougon-Cardoso and Peter Ryden and Trudy Torto-Alalibo and David Studholme and Yuanchao Wang and Joe Win and Jo Wood and Clifton, {Sandra W.} and Jane Rogers and {Van Den Ackerveken}, Guido and Jones, {Jonathan D.G.} and McDowell, {John M.} and Jim Beynon and Tyler, {Brett M.}",

year = "2010",

month = dec,

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doi = "10.1126/science.1195203",

language = "English",

volume = "330",

pages = "1549--1551",

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Baxter, L, Tripathy, S, Ishaque, N, Boot, N, Cabral, A, Kemen, E, Thines, M, Ah-Fong, A, Anderson, R, Badejoko, W, Bittner-Eddy, P, Boore, JL, Chibucos, MC, Coates, M, Dehal, P, Delehaunty, K, Dong, S, Downton, P, Dumas, B, Fabro, G, Fronick, C, Fuerstenberg, SI, Fulton, L, Gaulin, E, Govers, F, Hughes, L, Humphray, S, Jiang, RHY, Judelson, H, Kamoun, S, Kyung, K, Meijer, H, Minx, P, Morris, P, Nelson, J, Phuntumart, V, Qutob, D, Rehmany, A, Rougon-Cardoso, A, Ryden, P, Torto-Alalibo, T, Studholme, D, Wang, Y, Win, J, Wood, J, Clifton, SW, Rogers, J, Van Den Ackerveken, G, Jones, JDG, McDowell, JM, Beynon, J & Tyler, BM 2010, 'Signatures of adaptation to obligate biotrophy in the Hyaloperonospora arabidopsidis genome', Science, vol. 330, no. 6010, pp. 1549-1551. https://doi.org/10.1126/science.1195203

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T1 - Signatures of adaptation to obligate biotrophy in the Hyaloperonospora arabidopsidis genome

AU - Baxter, Laura

AU - Tripathy, Sucheta

AU - Ishaque, Naveed

AU - Boot, Nico

AU - Cabral, Adriana

AU - Kemen, Eric

AU - Thines, Marco

AU - Ah-Fong, Audrey

AU - Anderson, Ryan

AU - Badejoko, Wole

AU - Bittner-Eddy, Peter

AU - Boore, Jeffrey L.

AU - Chibucos, Marcus C.

AU - Coates, Mary

AU - Dehal, Paramvir

AU - Delehaunty, Kim

AU - Dong, Suomeng

AU - Downton, Polly

AU - Dumas, Bernard

AU - Fabro, Georgina

AU - Fronick, Catrina

AU - Fuerstenberg, Susan I.

AU - Fulton, Lucinda

AU - Gaulin, Elodie

AU - Govers, Francine

AU - Hughes, Linda

AU - Humphray, Sean

AU - Jiang, Rays H.Y.

AU - Judelson, Howard

AU - Kamoun, Sophien

AU - Kyung, Kim

AU - Meijer, Harold

AU - Minx, Patrick

AU - Morris, Paul

AU - Nelson, Joanne

AU - Phuntumart, Vipa

AU - Qutob, Dinah

AU - Rehmany, Anne

AU - Rougon-Cardoso, Alejandra

AU - Ryden, Peter

AU - Torto-Alalibo, Trudy

AU - Studholme, David

AU - Wang, Yuanchao

AU - Win, Joe

AU - Wood, Jo

AU - Clifton, Sandra W.

AU - Rogers, Jane

AU - Van Den Ackerveken, Guido

AU - Jones, Jonathan D.G.

AU - McDowell, John M.

AU - Beynon, Jim

AU - Tyler, Brett M.

PY - 2010/12/10

Y1 - 2010/12/10

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AB - Many oomycete and fungal plant pathogens are obligate biotrophs, which extract nutrients only from living plant tissue and cannot grow apart from their hosts. Although these pathogens cause substantial crop losses, little is known about the molecular basis or evolution of obligate biotrophy. Here, we report the genome sequence of the oomycete Hyaloperonospora arabidopsidis (Hpa), an obligate biotroph and natural pathogen of Arabidopsis thaliana. In comparison with genomes of related, hemibiotrophic Phytophthora species, the Hpa genome exhibits dramatic reductions in genes encoding (i) RXLR effectors and other secreted pathogenicity proteins, (ii) enzymes for assimilation of inorganic nitrogen and sulfur, and (iii) proteins associated with zoospore formation and motility. These attributes comprise a genomic signature of evolution toward obligate biotrophy.

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DO - 10.1126/science.1195203

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AN - SCOPUS:78650126298

SN - 0036-8075

VL - 330

SP - 1549

EP - 1551

JO - Science

JF - Science

IS - 6010

ER -

Signatures of adaptation to obligate biotrophy in the Hyaloperonospora arabidopsidis genome

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