Signaling protein SWAP-70 is required for efficient B cell homing to lymphoid organs

Glen Pearce, Veronique Angeli, Gwendalyn J. Randolph, Tobias Junt, Ulrich von Andrian, Hans Joachim Schnittler, Rolf Jessberger

Research output: Contribution to journalArticlepeer-review

62 Scopus citations

Abstract

The migration of B cells into secondary lymphoid organs is required for the generation of an effective immune response. Here we analyzed the involvement of SWAP-70, a Rac-interacting protein involved in actin rearrangement, in B cell entry into lymph nodes. We noted reduced migration of Swap70-/- B cells into lymph nodes in vivo. Swap70-/- B cells rolled and adhered, yet accumulated in lymph node high endothelial venules. This defect was not due to impaired integrin expression or chemotaxis. Instead, Swap70-/- B cells aberrantly regulated integrin-mediated adhesion. During attachment, Swap70-/- B cells showed defective polarization and did not form uropods or stabilize lamellipodia at a defined region. Thus, SWAP-70 selectively regulates processes essential for B cell entry into lymph nodes.

Original languageEnglish
Pages (from-to)827-834
Number of pages8
JournalNature immunology
Volume7
Issue number8
DOIs
StatePublished - Aug 2006

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