Signaling in dendritic spines and spine microdomains

Yao Chen; Bernardo L. Sabatini

doi:10.1016/j.conb.2012.03.003

Signaling in dendritic spines and spine microdomains

Yao Chen, Bernardo L. Sabatini

Research output: Contribution to journal › Review article › peer-review

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Abstract

The specialized morphology of dendritic spines creates an isolated compartment that allows for localized biochemical signaling. Recent studies have revealed complexity in the function of the spine head as a signaling domain and indicate that (1) the spine is functionally subdivided into multiple independent microdomains and (2) not all biochemical signals are equally compartmentalized within the spine. Here we review these findings as well as the developments in fluorescence microscopy that are making possible direct monitoring of signaling within spines and, in the future, within sub-spine microdomains.

Original language	English
Pages (from-to)	389-396
Number of pages	8
Journal	Current Opinion in Neurobiology
Volume	22
Issue number	3
DOIs	https://doi.org/10.1016/j.conb.2012.03.003
State	Published - Jun 2012

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abstract = "The specialized morphology of dendritic spines creates an isolated compartment that allows for localized biochemical signaling. Recent studies have revealed complexity in the function of the spine head as a signaling domain and indicate that (1) the spine is functionally subdivided into multiple independent microdomains and (2) not all biochemical signals are equally compartmentalized within the spine. Here we review these findings as well as the developments in fluorescence microscopy that are making possible direct monitoring of signaling within spines and, in the future, within sub-spine microdomains.",

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AB - The specialized morphology of dendritic spines creates an isolated compartment that allows for localized biochemical signaling. Recent studies have revealed complexity in the function of the spine head as a signaling domain and indicate that (1) the spine is functionally subdivided into multiple independent microdomains and (2) not all biochemical signals are equally compartmentalized within the spine. Here we review these findings as well as the developments in fluorescence microscopy that are making possible direct monitoring of signaling within spines and, in the future, within sub-spine microdomains.

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Signaling in dendritic spines and spine microdomains

Abstract

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