Signaling and transcription in T helper development

Kenneth M. Murphy, Wenjun Ouyang, J. David Farrar, Jianfei Yang, Sheila Ranganath, Helene Asnagli, Maryam Afkarian, Theresa L. Murphy

Research output: Contribution to journalReview articlepeer-review

518 Scopus citations

Abstract

The recognition of polarized T cell subsets defined by cytokine production was followed by a search to define the factors controlling this phenomenon. Suitable in vitro systems allowed the development of cytokine 'recipes' that induced rapid polarization of naive T cells into Th1 or Th2 populations. The next phase of work over the past several years has begun to define the intracellular processes set into motion during Th1/Th2 development, particularly by the strongly polarizing cytokines IL-12 and IL- 4. Although somewhat incomplete, what has emerged is a richly detailed tapestry of signaling and transcription, controlling an important T cell developmental switch. In addition several new mediators of control have emerged, including IL-18, the intriguing Th2-selective T1/ST2 product, and heterogeneity in dendritic cells capable of directing cytokine-independent Th development.

Original languageEnglish
Pages (from-to)451-494
Number of pages44
JournalAnnual Review of Immunology
Volume18
DOIs
StatePublished - Jun 27 2000

Keywords

  • Cytokines
  • Gene expression
  • Signaling
  • Th subsets
  • Transcription

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