TY - JOUR
T1 - Sialylated Milk Oligosaccharides Promote Microbiota-Dependent Growth in Models of Infant Undernutrition
AU - Charbonneau, Mark R.
AU - O'Donnell, David
AU - Blanton, Laura V.
AU - Totten, Sarah M.
AU - Davis, Jasmine C.C.
AU - Barratt, Michael J.
AU - Cheng, Jiye
AU - Guruge, Janaki
AU - Talcott, Michael
AU - Bain, James R.
AU - Muehlbauer, Michael J.
AU - Ilkayeva, Olga
AU - Wu, Chao
AU - Struckmeyer, Tedd
AU - Barile, Daniela
AU - Mangani, Charles
AU - Jorgensen, Josh
AU - Fan, Yue Mei
AU - Maleta, Kenneth
AU - Dewey, Kathryn G.
AU - Ashorn, Per
AU - Newgard, Christopher B.
AU - Lebrilla, Carlito
AU - Mills, David A.
AU - Gordon, Jeffrey I.
N1 - Publisher Copyright:
© 2016 Elsevier Inc.
PY - 2016/2/25
Y1 - 2016/2/25
N2 - Summary Identifying interventions that more effectively promote healthy growth of children with undernutrition is a pressing global health goal. Analysis of human milk oligosaccharides (HMOs) from 6-month-postpartum mothers in two Malawian birth cohorts revealed that sialylated HMOs are significantly less abundant in those with severely stunted infants. To explore this association, we colonized young germ-free mice with a consortium of bacterial strains cultured from the fecal microbiota of a 6-month-old stunted Malawian infant and fed recipient animals a prototypic Malawian diet with or without purified sialylated bovine milk oligosaccharides (S-BMO). S-BMO produced a microbiota-dependent augmentation of lean body mass gain, changed bone morphology, and altered liver, muscle, and brain metabolism in ways indicative of a greater ability to utilize nutrients for anabolism. These effects were also documented in gnotobiotic piglets using the same consortium and Malawian diet. These preclinical models indicate a causal, microbiota-dependent relationship between S-BMO and growth promotion.
AB - Summary Identifying interventions that more effectively promote healthy growth of children with undernutrition is a pressing global health goal. Analysis of human milk oligosaccharides (HMOs) from 6-month-postpartum mothers in two Malawian birth cohorts revealed that sialylated HMOs are significantly less abundant in those with severely stunted infants. To explore this association, we colonized young germ-free mice with a consortium of bacterial strains cultured from the fecal microbiota of a 6-month-old stunted Malawian infant and fed recipient animals a prototypic Malawian diet with or without purified sialylated bovine milk oligosaccharides (S-BMO). S-BMO produced a microbiota-dependent augmentation of lean body mass gain, changed bone morphology, and altered liver, muscle, and brain metabolism in ways indicative of a greater ability to utilize nutrients for anabolism. These effects were also documented in gnotobiotic piglets using the same consortium and Malawian diet. These preclinical models indicate a causal, microbiota-dependent relationship between S-BMO and growth promotion.
UR - http://www.scopus.com/inward/record.url?scp=84959476433&partnerID=8YFLogxK
U2 - 10.1016/j.cell.2016.01.024
DO - 10.1016/j.cell.2016.01.024
M3 - Article
C2 - 26898329
AN - SCOPUS:84959476433
SN - 0092-8674
VL - 164
SP - 859
EP - 871
JO - Cell
JF - Cell
IS - 5
ER -