TY - JOUR
T1 - Sialadenitis of Unknown Etiology
AU - Lindburg, Miranda
AU - Walvekar, Rohan R.
AU - Ogden, Allison
N1 - Publisher Copyright:
© 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2021/9
Y1 - 2021/9
N2 - Purpose of Review: Most sialadenitis is attributed to infection, obstruction, or underlying autoimmunity; however, there are several rare processes affecting the salivary glands without clear etiology. We review the available literature, specifically addressing presentation, evaluation, and treatment. Recent findings: Juvenile recurrent parotitis is a typically self-limiting entity occurring in school-age children and may be benefitted by sialendoscopy. Sclerosing polycystic adenosis is a rare cystic disorder of major salivary glands, diagnosed, and treated through surgery. Inflammatory pseudotumor is thought to be an abnormal focal immune response, mimicking a neoplasm. Rosai-Dorfman and Kimura diseases are considered lymphoproliferative disorders, and amyloidosis is a rare protein deposition disorder; all of which can affect the salivary glands. Summary: Unusual clinical entities should be considered for atypical or persistent sialadenitis of unknown etiology. Work-up generally includes biopsy for histologic diagnosis. Treatment is typically supportive and/or related to treating associated systemic disease. Surgical excision is reserved to establish diagnosis, for severe/refractory cases, or when malignancy is suspected.
AB - Purpose of Review: Most sialadenitis is attributed to infection, obstruction, or underlying autoimmunity; however, there are several rare processes affecting the salivary glands without clear etiology. We review the available literature, specifically addressing presentation, evaluation, and treatment. Recent findings: Juvenile recurrent parotitis is a typically self-limiting entity occurring in school-age children and may be benefitted by sialendoscopy. Sclerosing polycystic adenosis is a rare cystic disorder of major salivary glands, diagnosed, and treated through surgery. Inflammatory pseudotumor is thought to be an abnormal focal immune response, mimicking a neoplasm. Rosai-Dorfman and Kimura diseases are considered lymphoproliferative disorders, and amyloidosis is a rare protein deposition disorder; all of which can affect the salivary glands. Summary: Unusual clinical entities should be considered for atypical or persistent sialadenitis of unknown etiology. Work-up generally includes biopsy for histologic diagnosis. Treatment is typically supportive and/or related to treating associated systemic disease. Surgical excision is reserved to establish diagnosis, for severe/refractory cases, or when malignancy is suspected.
KW - Chronic sialadenitis
KW - Juvenile recurrent parotitis
KW - Kimura disease
KW - Parotid inflammatory pseudotumor
KW - Polycystic parotitis
KW - Rosai-Dorfman disease
KW - Salivary amyloidosis
KW - Sclerosing polycystic adenosis
UR - http://www.scopus.com/inward/record.url?scp=85106736155&partnerID=8YFLogxK
U2 - 10.1007/s40136-021-00361-7
DO - 10.1007/s40136-021-00361-7
M3 - Review article
AN - SCOPUS:85106736155
SN - 2167-583X
VL - 9
SP - 378
EP - 382
JO - Current Otorhinolaryngology Reports
JF - Current Otorhinolaryngology Reports
IS - 3
ER -