Sialadenitis of Unknown Etiology

Miranda Lindburg, Rohan R. Walvekar, Allison Ogden

Research output: Contribution to journalReview articlepeer-review


Purpose of Review: Most sialadenitis is attributed to infection, obstruction, or underlying autoimmunity; however, there are several rare processes affecting the salivary glands without clear etiology. We review the available literature, specifically addressing presentation, evaluation, and treatment. Recent findings: Juvenile recurrent parotitis is a typically self-limiting entity occurring in school-age children and may be benefitted by sialendoscopy. Sclerosing polycystic adenosis is a rare cystic disorder of major salivary glands, diagnosed, and treated through surgery. Inflammatory pseudotumor is thought to be an abnormal focal immune response, mimicking a neoplasm. Rosai-Dorfman and Kimura diseases are considered lymphoproliferative disorders, and amyloidosis is a rare protein deposition disorder; all of which can affect the salivary glands. Summary: Unusual clinical entities should be considered for atypical or persistent sialadenitis of unknown etiology. Work-up generally includes biopsy for histologic diagnosis. Treatment is typically supportive and/or related to treating associated systemic disease. Surgical excision is reserved to establish diagnosis, for severe/refractory cases, or when malignancy is suspected.

Original languageEnglish
Pages (from-to)378-382
Number of pages5
JournalCurrent Otorhinolaryngology Reports
Issue number3
StatePublished - Sep 2021


  • Chronic sialadenitis
  • Juvenile recurrent parotitis
  • Kimura disease
  • Parotid inflammatory pseudotumor
  • Polycystic parotitis
  • Rosai-Dorfman disease
  • Salivary amyloidosis
  • Sclerosing polycystic adenosis


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