SIAH ubiquitin ligases target the nonreceptor tyrosine kinase ACK1 for ubiquitinylation and proteasomal degradation

Keyphrases

• Receptor Tyrosine Kinase 100%
• Proteasomal Degradation 100%
• Ubiquitin Ligase 100%
• Seven in Absentia 100%
• Ubiquitinylation 100%
• SIAH1 83%
• SIAH2 66%
• Binding Motif 33%
• Cancer Therapy 16%
• Non-associated 16%
• Knockdown 16%
• Molecular Mechanism 16%
• Protein Degradation 16%
• Protein-protein Interaction 16%
• Transformed Cells 16%
• In Cancer 16%
• C-terminus 16%
• Estrogen Receptor 16%
• Interacting Proteins 16%
• Point mutant 16%
• Receptor Activation 16%
• Cell Transformation 16%
• Tumor Metastasis 16%
• Epidermal Growth Factor 16%
• Negative Effects 16%
• Negative Regulator 16%
• Tumor Progression 16%
• Human Breast Cancer Cells 16%
• Kinase Activity 16%
• Deletion mutant 16%
• Proteasomal Activity 16%
• Degradation Pathway 16%
• Endolysosomal System 16%
• ACK1 16%
• Interaction Studies 16%
• Chemical Inhibitors 16%
• Yeast Two-hybrid Screen 16%
• Homo Sapiens 16%
• Pathway Targeting 16%
• Activated Cdc42-associated Kinase 16%
• Degradation Analysis 16%

Biochemistry, Genetics and Molecular Biology

• Kinase 100%
• Phosphotransferase 100%
• Receptor Tyrosine Kinase 100%
• Tyrosine Kinase 100%
• Ubiquitin Ligase 100%
• Cancer Cell 5%
• Tumor Progression 5%
• C-Terminus 5%
• Protein-Protein Interaction 5%
• Estrogen Receptor 5%
• Protein Catabolism 5%
• Cell Transformation 5%
• Yeast Two-Hybrid Screening 5%
• Epidermal Growth Factor 5%
• Interaction Study 5%
• Messenger RNA 5%
• Homo sapiens 5%