TY - JOUR
T1 - Short-term weight gain and breast cancer risk by hormone receptor classification among pre- and postmenopausal women
AU - Rosner, Bernard
AU - Eliassen, A. Heather
AU - Toriola, Adetunji T.
AU - Hankinson, Susan E.
AU - Willett, Walter C.
AU - Natarajan, Loki
AU - Colditz, Graham A.
N1 - Publisher Copyright:
© 2015, The Author(s).
PY - 2015/4/1
Y1 - 2015/4/1
N2 - Obesity is well established as a cause of postmenopausal breast cancer incidence and mortality. In contrast, adiposity in early life reduces breast cancer incidence. However, whether short-term weight change influences breast cancer risk is not well known. We followed a cohort of 77,232 women from 1980 to 2006 (1,445,578 person-years), with routinely updated risk factor information, documenting 4196 incident cases of invasive breast cancer. ER and PR status were obtained from pathology reports and medical records yielding a total of 2033 ER+/PR+ tumors, 595 ER−/PR− tumors, 512 ER+/PR− tumors. The log incidence breast cancer model was used to assess the association of short-term weight gain (over past 4 years) while controlling for average BMI before and after menopause. Short-term weight change was significantly associated with breast cancer risk (RR 1.20; 95 % CI 1.09–1.33) for a 4-year weight gain of ≥15 lbs versus no change (≤5 lbs) (P_trend < 0.001). The association was stronger for premenopausal women (RR 1.38; 95 % CI 1.13–1.69) (P_trend = 0.004) than for postmenopausal women (RR 1.10; 95 % CI 0.97–1.25) (P_trend = 0.063). Short-term weight gain during premenopause had a stronger association for ER+/PR− (RR per 25 lb weight gain = 2.19; 95 % CI 1.33–3.61, P = 0.002) and ER−/PR− breast cancer (RR per 25 lb weight gain = 1.61; 95 % CI 1.09–2.38, P = 0.016) than for ER+/PR+ breast cancer (RR per 25 lb weight gain = 1.13; 95 % CI 0.89–1.43, P = 0.32). There are deleterious effects of short-term weight gain, particularly during pre-menopause, even after controlling for average BMI before and after menopause. The association was stronger for ER+/PR− and ER−/PR− than for ER+/PR+ breast cancer.
AB - Obesity is well established as a cause of postmenopausal breast cancer incidence and mortality. In contrast, adiposity in early life reduces breast cancer incidence. However, whether short-term weight change influences breast cancer risk is not well known. We followed a cohort of 77,232 women from 1980 to 2006 (1,445,578 person-years), with routinely updated risk factor information, documenting 4196 incident cases of invasive breast cancer. ER and PR status were obtained from pathology reports and medical records yielding a total of 2033 ER+/PR+ tumors, 595 ER−/PR− tumors, 512 ER+/PR− tumors. The log incidence breast cancer model was used to assess the association of short-term weight gain (over past 4 years) while controlling for average BMI before and after menopause. Short-term weight change was significantly associated with breast cancer risk (RR 1.20; 95 % CI 1.09–1.33) for a 4-year weight gain of ≥15 lbs versus no change (≤5 lbs) (P_trend < 0.001). The association was stronger for premenopausal women (RR 1.38; 95 % CI 1.13–1.69) (P_trend = 0.004) than for postmenopausal women (RR 1.10; 95 % CI 0.97–1.25) (P_trend = 0.063). Short-term weight gain during premenopause had a stronger association for ER+/PR− (RR per 25 lb weight gain = 2.19; 95 % CI 1.33–3.61, P = 0.002) and ER−/PR− breast cancer (RR per 25 lb weight gain = 1.61; 95 % CI 1.09–2.38, P = 0.016) than for ER+/PR+ breast cancer (RR per 25 lb weight gain = 1.13; 95 % CI 0.89–1.43, P = 0.32). There are deleterious effects of short-term weight gain, particularly during pre-menopause, even after controlling for average BMI before and after menopause. The association was stronger for ER+/PR− and ER−/PR− than for ER+/PR+ breast cancer.
KW - BMI
KW - Breast cancer risk
KW - Hormone receptor classification
KW - Obesity
UR - http://www.scopus.com/inward/record.url?scp=84939985253&partnerID=8YFLogxK
U2 - 10.1007/s10549-015-3344-0
DO - 10.1007/s10549-015-3344-0
M3 - Article
C2 - 25796612
AN - SCOPUS:84939985253
SN - 0167-6806
VL - 150
SP - 643
EP - 653
JO - Breast Cancer Research and Treatment
JF - Breast Cancer Research and Treatment
IS - 3
ER -