TY - JOUR
T1 - Short-term weight gain and breast cancer risk by hormone receptor classification among pre- and postmenopausal women
AU - Rosner, Bernard
AU - Eliassen, A. Heather
AU - Toriola, Adetunji T.
AU - Hankinson, Susan E.
AU - Willett, Walter C.
AU - Natarajan, Loki
AU - Colditz, Graham A.
N1 - Funding Information:
This work was supported by grants from the National Cancer Institutes at the National Institutes of Health (U54 CA155626, U54 CA155435, U54 CA155496, and PO1 CA 087969). This study was approved by the Brigham and Women’s Hospital Human Studies Committee. The funders have not participated in the conduct of this study. The authors would like to thank the participants and staff of the Nurses’ Health Study for their valuable contributions as well as the following state cancer registries for their help: AL, AZ, AR, CA, CO, CT, DE, FL, GA, ID, IL, IN, IA, KY, LA, ME, MD, MA, MI, NE, NH, NJ, NY, NC, ND, OH, OK, OR, PA, RI, SC, TN, TX, VA, WA, WY. The authors assume full responsibility for analyses and interpretation of these data.
Publisher Copyright:
© 2015, The Author(s).
PY - 2015/4/1
Y1 - 2015/4/1
N2 - Obesity is well established as a cause of postmenopausal breast cancer incidence and mortality. In contrast, adiposity in early life reduces breast cancer incidence. However, whether short-term weight change influences breast cancer risk is not well known. We followed a cohort of 77,232 women from 1980 to 2006 (1,445,578 person-years), with routinely updated risk factor information, documenting 4196 incident cases of invasive breast cancer. ER and PR status were obtained from pathology reports and medical records yielding a total of 2033 ER+/PR+ tumors, 595 ER−/PR− tumors, 512 ER+/PR− tumors. The log incidence breast cancer model was used to assess the association of short-term weight gain (over past 4 years) while controlling for average BMI before and after menopause. Short-term weight change was significantly associated with breast cancer risk (RR 1.20; 95 % CI 1.09–1.33) for a 4-year weight gain of ≥15 lbs versus no change (≤5 lbs) (P_trend < 0.001). The association was stronger for premenopausal women (RR 1.38; 95 % CI 1.13–1.69) (P_trend = 0.004) than for postmenopausal women (RR 1.10; 95 % CI 0.97–1.25) (P_trend = 0.063). Short-term weight gain during premenopause had a stronger association for ER+/PR− (RR per 25 lb weight gain = 2.19; 95 % CI 1.33–3.61, P = 0.002) and ER−/PR− breast cancer (RR per 25 lb weight gain = 1.61; 95 % CI 1.09–2.38, P = 0.016) than for ER+/PR+ breast cancer (RR per 25 lb weight gain = 1.13; 95 % CI 0.89–1.43, P = 0.32). There are deleterious effects of short-term weight gain, particularly during pre-menopause, even after controlling for average BMI before and after menopause. The association was stronger for ER+/PR− and ER−/PR− than for ER+/PR+ breast cancer.
AB - Obesity is well established as a cause of postmenopausal breast cancer incidence and mortality. In contrast, adiposity in early life reduces breast cancer incidence. However, whether short-term weight change influences breast cancer risk is not well known. We followed a cohort of 77,232 women from 1980 to 2006 (1,445,578 person-years), with routinely updated risk factor information, documenting 4196 incident cases of invasive breast cancer. ER and PR status were obtained from pathology reports and medical records yielding a total of 2033 ER+/PR+ tumors, 595 ER−/PR− tumors, 512 ER+/PR− tumors. The log incidence breast cancer model was used to assess the association of short-term weight gain (over past 4 years) while controlling for average BMI before and after menopause. Short-term weight change was significantly associated with breast cancer risk (RR 1.20; 95 % CI 1.09–1.33) for a 4-year weight gain of ≥15 lbs versus no change (≤5 lbs) (P_trend < 0.001). The association was stronger for premenopausal women (RR 1.38; 95 % CI 1.13–1.69) (P_trend = 0.004) than for postmenopausal women (RR 1.10; 95 % CI 0.97–1.25) (P_trend = 0.063). Short-term weight gain during premenopause had a stronger association for ER+/PR− (RR per 25 lb weight gain = 2.19; 95 % CI 1.33–3.61, P = 0.002) and ER−/PR− breast cancer (RR per 25 lb weight gain = 1.61; 95 % CI 1.09–2.38, P = 0.016) than for ER+/PR+ breast cancer (RR per 25 lb weight gain = 1.13; 95 % CI 0.89–1.43, P = 0.32). There are deleterious effects of short-term weight gain, particularly during pre-menopause, even after controlling for average BMI before and after menopause. The association was stronger for ER+/PR− and ER−/PR− than for ER+/PR+ breast cancer.
KW - BMI
KW - Breast cancer risk
KW - Hormone receptor classification
KW - Obesity
UR - http://www.scopus.com/inward/record.url?scp=84939985253&partnerID=8YFLogxK
U2 - 10.1007/s10549-015-3344-0
DO - 10.1007/s10549-015-3344-0
M3 - Article
C2 - 25796612
AN - SCOPUS:84939985253
VL - 150
SP - 643
EP - 653
JO - Breast Cancer Research and Treatment
JF - Breast Cancer Research and Treatment
SN - 0167-6806
IS - 3
ER -